Auriacombe M, Tignol J, Le Moal M, Stinus L
Inserm U. 259, Université de Bordeaux II, France.
Biol Psychiatry. 1990 Oct 15;28(8):650-6. doi: 10.1016/0006-3223(90)90451-7.
Transcutaneous electrostimulation is a somewhat controversial technique used in the management of the opiate withdrawal syndrome. We report an animal study of a particular transcutaneous electrostimulation called transcutaneous cranial electrostimulation, based on a technique used for many years on heroin addicts for the rapid severance of their addiction, which has been validated in a clinical setting by a double-blind trial. This technique involves the application of an intermittent high-frequency current (Limoge's current). Our experimental data show that this transcutaneous cranial electrostimulation increases morphine analgesia by threefold on the tail flick latency measure and produces a 48% attenuation of the abstinence syndrome observed after abrupt cessation of morphine administration. These results were obtained using a double-blind paradigm.
经皮电刺激是一种用于治疗阿片类药物戒断综合征的颇具争议的技术。我们报告了一项关于一种特殊经皮电刺激的动物研究，这种刺激被称为经皮颅电刺激，它基于一种多年来用于海洛因成瘾者以快速戒除成瘾的技术，该技术已在临床环境中通过双盲试验得到验证。这种技术涉及施加间歇性高频电流（利摩日电流）。我们的实验数据表明，这种经皮颅电刺激在甩尾潜伏期测量中使吗啡镇痛效果提高了三倍，并使吗啡给药突然停止后观察到的戒断综合征减轻了48%。这些结果是使用双盲范式获得的。
