Beaulieu C L, Thorn B E
Behav Neurosci. 1986 Aug;100(4):504-11. doi: 10.1037//0735-7044.100.4.504.
Male albino rats were stereotaxically implanted with a bipolar stimulating electrode in the periaqueductal gray and also received a subcutaneous surgical implantation of a 72-mg morphine or a placebo pellet. Seventy-two hours following pellet implantation, naloxone-precipitated withdrawal was induced. Opiate withdrawal behaviors were observed and quantified. Animals then received focal brain stimulation for 30 min after which they were again observed for opiate withdrawal behaviors. The data suggest that focal brain stimulation attenuates morphine withdrawal behaviors, specifically the recessive behaviors associated with autonomic changes. These findings are consistent with those of other studies, from which it is speculated that more than one system is involved in the mediation of opioid dependence and analgesia.
雄性白化大鼠通过立体定位将双极刺激电极植入中脑导水管周围灰质，并皮下手术植入72毫克吗啡或安慰剂药丸。药丸植入72小时后，诱发纳洛酮促发的戒断反应。观察并量化阿片类药物戒断行为。然后对动物进行30分钟的局灶性脑刺激，之后再次观察其阿片类药物戒断行为。数据表明，局灶性脑刺激可减轻吗啡戒断行为，特别是与自主神经变化相关的隐性行为。这些发现与其他研究结果一致，据此推测，阿片类药物依赖和镇痛的调节涉及多个系统。
