Institute of Preventive Medicine, Copenhagen University Hospitals, Copenhagen Capital Region, Øster Søgade 18, DK-1357 Copenhagen K, Denmark.
Br J Nutr. 2011 Oct;106(8):1245-52. doi: 10.1017/S0007114511001474. Epub 2011 May 18.
Intake of trans-fatty acids (TFA), especially industrially produced TFA (I-TFA), has been associated with the risk of CHD through influence on serum lipid levels. Other causal pathways remain less investigated. In the present cross-sectional study of middle-aged men representing a broad range of BMI, the association between intake of TFA, I-TFA and ruminant TFA (R-TFA) and obesity-associated risk markers of CHD was assessed. The study comprised 393 Danish men (median age 49 years) with a median BMI of 28·4 kg/m(2). Intake of TFA was estimated based on 7 d dietary records, whereas outcomes of interest (waist circumference, sagittal abdominal diameter, percentage of truncal fat, C-reactive protein, IL-6, blood lipids, blood pressure, HbA1c and insulin sensitivity index) were obtained through clinical examination. The associations were assessed by linear regression analysis. The median intake of total TFA among the 393 men was 1·3 g/d, covering a daily I-TFA intake of 0·4 g (10-90th percentile 0·0-1·0) and R-TFA intake of 0·9 g (10-90th percentile 0·4-1·8). Intake of these amounts of TFA showed no significant associations with abdominal fatness, inflammatory markers, blood lipids, blood pressure and insulin homeostasis. Among middle-aged men with a generally low intake of TFA, neither I-TFA nor R-TFA was significantly related to obesity-associated risk markers of CHD. The decreased average intake of I-TFA in Denmark since 1995 is suggested to effectively prevent occurrence of the adverse metabolic changes and health consequences, which have formerly been observed in relation to, especially, I-TFA intake.
反式脂肪酸（TFA）的摄入，尤其是工业生产的 TFA（I-TFA），会通过影响血清脂质水平，增加冠心病（CHD）的发病风险。其他因果途径则研究较少。在这项针对中年男性的横断面研究中，这些男性代表了广泛的 BMI 范围，研究评估了 TFA、I-TFA 和反刍动物 TFA（R-TFA）的摄入量与肥胖相关的 CHD 风险标志物之间的关系。该研究包括 393 名丹麦男性（中位年龄 49 岁），中位 BMI 为 28.4kg/m²。TFA 的摄入量是根据 7 天的饮食记录来估计的，而感兴趣的结果（腰围、矢状腹部直径、躯干脂肪百分比、C 反应蛋白、IL-6、血脂、血压、HbA1c 和胰岛素敏感性指数）则通过临床检查获得。采用线性回归分析评估这些关联。393 名男性的总 TFA 摄入量中位数为 1.3g/d，其中 I-TFA 的日摄入量为 0.4g（10-90 分位数为 0.0-1.0），R-TFA 的日摄入量为 0.9g（10-90 分位数为 0.4-1.8）。这些 TFA 的摄入量与腹部肥胖、炎症标志物、血脂、血压和胰岛素稳态均无显著相关性。在 TFA 摄入量普遍较低的中年男性中，I-TFA 和 R-TFA 与 CHD 肥胖相关的风险标志物均无显著相关性。自 1995 年以来，丹麦 I-TFA 的平均摄入量减少，这被认为有效预防了以前观察到的与 I-TFA 摄入相关的不良代谢变化和健康后果。
