Department of Biochemistry, Pharmacy Faculty, Istanbul University, 34116, Istanbul, Turkey.
Anticancer Res. 2011 Jun;31(6):2225-9.
The purpose of the present study was to investigate the possible association of paraoxonase-1 (PON1) 192/55 polymorphisms with lung cancer (LC) risk in a Turkish population.
A population-based, case-control study was carried out, including 223 patients with LC and 234 controls. The frequencies of PON1 192/55 genotypes were compared in patient and control groups using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.
Distribution of PON1 192 R (+) genotype was found to be significantly higher in patients with LC compared to the controls (odds ratio: 1.497, 95% confidence interval: 1.034-2.166). This difference was especially noteworthy in patients with small cell carcinoma and squamous cell carcinoma.
This is the first case-control study on the association between PON1 polymorphisms and LC susceptibility in a Turkish population. Our results suggest that PON1 192 polymorphsim is associated with an increased risk of LC in the Turkish population and may be a useful genetic marker for small cell and squamous cell carcinoma.
本研究旨在探讨对氧磷酶 1（PON1）192/55 多态性与土耳其人群肺癌（LC）风险的可能关联。
进行了一项基于人群的病例对照研究，包括 223 例 LC 患者和 234 例对照。使用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）分析比较患者和对照组中 PON1 192/55 基因型的频率。
与对照组相比，LC 患者中 PON1 192 R（+）基因型的分布明显更高（比值比：1.497，95%置信区间：1.034-2.166）。在小细胞癌和鳞状细胞癌患者中，这种差异尤为明显。
这是在土耳其人群中进行的关于 PON1 多态性与 LC 易感性之间关联的首个病例对照研究。我们的结果表明，PON1 192 多态性与 LC 风险增加相关，并且可能是小细胞癌和鳞状细胞癌的有用遗传标志物。
