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NAF，一种在小鼠乳腺肿瘤病毒开放阅读框区域编码的反式调节负向作用因子。

naf, a trans-regulating negative-acting factor encoded within the mouse mammary tumor virus open reading frame region.

作者信息

Salmons B, Erfle V, Brem G, Günzburg W H

机构信息

GSF-München, Abteilung für Molekulare Zellpathologie, Neuherberg, Federal Republic of Germany.

出版信息

J Virol. 1990 Dec;64(12):6355-9. doi: 10.1128/JVI.64.12.6355-6359.1990.

DOI:10.1128/JVI.64.12.6355-6359.1990
PMID:2173798
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC248820/
Abstract

The mouse mammary tumor virus (MMTV) long terminal repeat (LTR) open reading frame (ORF) encodes a negative acting factor (naf). In our test system, naf mediates its effect in trans on another MMTV provirus in which the 5' LTR has been replaced by that of Rous sarcoma virus. naf effects are evidenced at the level of transcriptional initiation rather than as reduced mRNA stability. The introduction of a premature termination codon into the MMTV LTR-encoded ORF abolishes the transcriptional down regulation localizing naf within the ORF. In addition, sequences in the gag/pol genes between +320 and +646 and between +3626 and +4590 relative to the site of transcription initiation are also involved in the MMTV-mediated transcriptional down regulation.

摘要

小鼠乳腺肿瘤病毒（MMTV）长末端重复序列（LTR）开放阅读框（ORF）编码一种负向作用因子（naf）。在我们的测试系统中，naf通过反式作用于另一种MMTV前病毒来介导其效应，该前病毒的5' LTR已被劳氏肉瘤病毒的5' LTR所取代。naf的作用在转录起始水平得以体现，而非表现为mRNA稳定性降低。在MMTV LTR编码的ORF中引入一个提前终止密码子会消除转录下调，从而将naf定位在该ORF内。此外，相对于转录起始位点，gag/pol基因中位于+320至+646以及+3626至+4590之间的序列也参与了MMTV介导的转录下调。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68f1/248820/58b366ceb902/jvirol00067-0675-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68f1/248820/536fd5290a54/jvirol00067-0675-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68f1/248820/e9eb1208f257/jvirol00067-0675-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68f1/248820/58b366ceb902/jvirol00067-0675-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68f1/248820/536fd5290a54/jvirol00067-0675-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68f1/248820/e9eb1208f257/jvirol00067-0675-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68f1/248820/58b366ceb902/jvirol00067-0675-c.jpg

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