晚期头颈部皮肤鳞状细胞癌中的 EGFR 表达。
EGFR expression in advanced head and neck cutaneous squamous cell carcinoma.
机构信息
Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
出版信息
Head Neck. 2012 May;34(5):681-6. doi: 10.1002/hed.21802. Epub 2011 Jul 7.
Abstract
BACKGROUND
The significance of epidermal growth factor receptor (EGFR) expression in advanced cutaneous squamous cell carcinoma (SCC) of the head and neck remains poorly understood.
METHODS
We performed a retrospective review of patients with advanced-stage (stage III or stage IV) cutaneous SCC of the head and neck (n = 56).
RESULTS
The majority of patients (91%) had stage III disease, with 54% having regional metastasis and 9% with distant metastasis. Two-year survival was 64% and the 5-year survival was 56%. EGFR was found to be overexpressed in 56% of primary tumors and 58% of regional metastatic disease. Overall survival did not correlate with EGFR (p = .47) expression in primary lesions, nor was it associated with an increase in regional (p = .74) or distant metastasis (p = .56). Furthermore, there was no correlation between clinicopathologic characteristics and EGFR expression
CONCLUSIONS
These data do not suggest upregulation of EGFR is associated with poor survival or aggressive disease.
摘要
背景
表皮生长因子受体（EGFR）在头颈部晚期皮肤鳞状细胞癌（SCC）中的表达意义仍不清楚。
方法
我们对 56 例头颈部晚期（III 期或 IV 期）皮肤 SCC 患者进行了回顾性研究。
结果
大多数患者（91%）患有 III 期疾病，54%有区域性转移，9%有远处转移。两年生存率为 64%，五年生存率为 56%。在原发肿瘤和 58%的区域性转移疾病中发现 EGFR 过表达。EGFR 在原发灶中的表达与总体生存率无关（p =.47），也与区域性（p =.74）或远处转移（p =.56）无关。此外，EGFR 表达与临床病理特征之间无相关性。
结论
这些数据表明，EGFR 的上调与不良预后或侵袭性疾病无关。
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