Da Vinci Clinic, Center for Regenerative and Hyperbaric Medicine, Nieuwendijk 49, 5664 HB Geldrop, the Netherlands.
Curr Pharm Biotechnol. 2012 Jun;13(7):1163-72. doi: 10.2174/138920112800624346.
Tissue repair at wound sites begins with clot formation, and subsequently platelet degranulation with the release of platelet growth factors, which are necessary and well-regulated processes to achieve wound healing. Platelet-derived growth factors are biologically active substances that enhance tissue repair mechanisms, such as chemotaxis, cell proliferation, angiogenesis, extracellular matrix deposition, and remodeling. This review describes the biological background and results on the topical use of autologous platelet-rich plasma and platelet gel in gynecologic, cardiac, and general surgical procedures, including chronic wound management and soft-tissue injuries.
组织在创伤部位的修复始于血栓形成，随后血小板脱颗粒并释放血小板生长因子，这是实现伤口愈合所必需的且受到良好调控的过程。血小板衍生生长因子是生物活性物质，可增强组织修复机制，如趋化性、细胞增殖、血管生成、细胞外基质沉积和重塑。本文综述了自体富含血小板血浆和血小板凝胶在妇科、心脏和普通外科手术中的应用的生物学背景和结果，包括慢性伤口管理和软组织损伤。
