Department of Medicine, Addenbrooke's Hospital, Cambridge, UK.
J Formos Med Assoc. 2011 Jun;110(6):350-62. doi: 10.1016/S0929-6646(11)60053-3.
Human immunodeficiency virus (HIV), the causative agent of AIDS, is a retrovirus. It is estimated that, while in the cell, it interacts with almost 10% of cellular proteins. Several of these have evolved to protect the cell from infection with retroviruses and are known as "restriction factors". Restriction factors tell us much about how the virus functions and open up new paradigms for exploring novel antiviral therapeutics. This article gives an update on the three best studied restriction factors, their putative mechanisms of action and how the virus has overcome their effects, together with an indication of novel therapeutic approaches based on this knowledge.
人类免疫缺陷病毒（HIV），即艾滋病的病原体，是一种逆转录病毒。据估计，HIV 在细胞内与近 10%的细胞蛋白相互作用。其中一些蛋白进化为可以保护细胞免受逆转录病毒感染，被称为“限制因子”。限制因子使我们对病毒的功能有了更深入的了解，并为探索新型抗病毒治疗方法开辟了新的范例。本文综述了研究最为深入的三种限制因子，它们的作用机制以及病毒是如何克服其作用的，同时还介绍了基于这些知识的新型治疗方法。
