Lipid Metabolism Laboratory, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.
Atherosclerosis. 2011 Aug;217(2):543-8. doi: 10.1016/j.atherosclerosis.2011.05.035. Epub 2011 Jun 12.
Our aim was to determine whether plasma adiponectin levels were an independent predictor of coronary heart disease (CHD) risk.
Plasma adiponectin levels were measured in 3188 male and female participants from cycle 6 of the Framingham offspring Study (mean age: 57 years in both men and women; BMI: 28.5 kg/m(2) in men and 27.3 kg/m(2) in women), using a novel fully automated assay. Plasma adiponectin levels (median [25th percentile, 75th percentile]) were significantly higher in female than in male CHD-free subjects (14.8 [10.7,20.5] μg/ml versus 9.0 [7.0,12.2] μg/ml, p<0.001). Participants were followed for a mean of 7.5 years. After adjustment for age, BMI, smoking status, systolic blood pressure, treatment for hypertension, diabetes, use of cholesterol-lowering medication, total cholesterol level, high-density lipoprotein cholesterol level, and C-reactive protein levels, a higher plasma adiponectin level was a significant predictor of lower risk of future CHD events (n=117) in men (HR 0.49, p<0.0022). A similar trend was observed in women, but was no longer significant after multivariate adjustments.
Our data indicate that plasma adiponectin levels are an independent predictor of CHD in Caucasian men initially free of CHD.
本研究旨在确定血浆脂联素水平是否是冠心病（CHD）风险的独立预测因子。
在弗雷明汉后代研究（Framingham Offspring Study）第 6 周期的 3188 名男性和女性参与者（男女平均年龄均为 57 岁；男性 BMI 为 28.5kg/m2，女性 BMI 为 27.3kg/m2）中，采用新型全自动检测法测定血浆脂联素水平。无 CHD 的女性参与者的血浆脂联素水平（中位数[25 分位数，75 分位数]）明显高于男性（14.8[10.7，20.5]μg/ml 比 9.0[7.0，12.2]μg/ml，p<0.001）。参与者的平均随访时间为 7.5 年。在校正年龄、BMI、吸烟状况、收缩压、高血压治疗、糖尿病、使用降脂药物、总胆固醇水平、高密度脂蛋白胆固醇水平和 C 反应蛋白水平后，较高的血浆脂联素水平是男性未来发生 CHD 事件（n=117）风险降低的显著预测因子（HR 0.49，p<0.0022）。在女性中观察到类似的趋势，但在进行多变量调整后不再显著。
我们的数据表明，在最初无 CHD 的白人男性中，血浆脂联素水平是 CHD 的独立预测因子。
