性别差异与心血管代谢风险：危险因素的重要性。
Gender Differences and Cardiometabolic Risk: The Importance of the Risk Factors.
机构信息
Department of Radiology, Fondazione G. Monasterio CNR-Regione Toscana, 56124 Pisa, Italy.
Department of Medical Sciences and Public Health, University of Cagliari, 09042 Cagliari, Italy.
出版信息
Int J Mol Sci. 2023 Jan 13;24(2):1588. doi: 10.3390/ijms24021588.
Abstract
Metabolic syndrome (Mets) is a clinical condition characterized by a cluster of major risk factors for cardiovascular disease (CVD) and type 2 diabetes: proatherogenic dyslipidemia, elevated blood pressure, dysglycemia, and abdominal obesity. Each risk factor has an independent effect, but, when aggregated, they become synergistic, doubling the risk of developing cardiovascular diseases and causing a 1.5-fold increase in all-cause mortality. We will highlight gender differences in the epidemiology, etiology, pathophysiology, and clinical expression of the aforementioned Mets components. Moreover, we will discuss gender differences in new biochemical markers of metabolic syndrome and cardiovascular risk.
摘要
代谢综合征（Mets）是一种临床病症，其特征是一组主要的心血管疾病（CVD）和 2 型糖尿病风险因素：动脉粥样硬化性血脂异常、血压升高、血糖异常和腹部肥胖。每个风险因素都有独立的作用，但当它们聚集在一起时，就会产生协同作用，使患心血管疾病的风险增加一倍，并使全因死亡率增加 1.5 倍。我们将重点介绍上述 Mets 成分在流行病学、病因学、病理生理学和临床表达方面的性别差异。此外，我们还将讨论代谢综合征和心血管风险的新生化标志物的性别差异。
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