Department of Pharmacology, Sultan Qaboos University, Al Khod, Oman.
Phytomedicine. 2011 Oct 15;18(13):1176-80. doi: 10.1016/j.phymed.2011.03.005. Epub 2011 Jul 7.
Chronic renal failure (CRF) occurring naturally in patients or induced by subtotal nephrectomy in rats induces several alterations in the cardiovascular system (CVS). However, the effect of chemically induced CRF in rats on the CVS is less well known. We induced CRF in rats by feeding adenine (0.75%, w/w, four weeks) and investigated the effect of the ensuing CRF on the systolic and diastolic blood pressure (BP) and heart rate (HR). Further, we investigated the effect of giving acacia gum (AG, 10%, w/v) in the drinking water concomitantly with adenine on the above parameters. AG has been previously shown to ameliorate the severity of CRF in humans and rats. We confirmed here that adenine-induced CRF significantly increased the plasma concentrations of urea and creatinine, and reduced creatinine clearance. Additionally, it significantly increased both systolic and diastolic BP, with no significant effect on HR. Both of these actions were significantly mitigated by AG treatment. The antihypertensive angiotenisn-converting enzyme inhibitor lisinopril (10mg/kg) was given by gavage to rats concomitantly with adenine, significantly reduced the rise in blood pressure induced by adenine. In conclusion, adenine-induced CRF in rats significantly increased BP, and this was significantly mitigated by administration of AG. Possible mechanisms of these changes and the protective effect of AG will be investigated.
慢性肾衰竭（CRF）在患者中自然发生或在大鼠中通过肾部分切除术诱发，会引起心血管系统（CVS）的多种改变。然而，化学诱导的 CRF 在大鼠中对 CVS 的影响知之甚少。我们通过给大鼠喂食腺嘌呤（0.75%，w/w，四周）来诱导 CRF，并研究随之而来的 CRF 对收缩压和舒张压（BP）和心率（HR）的影响。此外，我们研究了同时在饮水中给予阿拉伯树胶（AG，10%，w/v）对上述参数的影响。AG 先前已被证明可改善人类和大鼠 CRF 的严重程度。我们在这里证实，腺嘌呤诱导的 CRF 显著增加了血浆中尿素和肌酐的浓度，并降低了肌酐清除率。此外，它显著增加了收缩压和舒张压，对心率没有显著影响。AG 治疗显著减轻了这两种作用。血管紧张素转换酶抑制剂赖诺普利（10mg/kg）通过管饲同时给予大鼠腺嘌呤，显著降低了腺嘌呤引起的血压升高。总之，腺嘌呤诱导的大鼠 CRF 显著增加了血压，而 AG 的给予显著减轻了这种升高。这些变化的可能机制和 AG 的保护作用将被研究。
