Centre de Recherches sur la Cognition et l'Apprentissage, UMR CNRS 6234, Université de Poitiers, France.
J Neurol Sci. 2011 Nov 15;310(1-2):241-7. doi: 10.1016/j.jns.2011.06.033. Epub 2011 Jul 13.
Subjective emotional experience is thought to rely on a large cortical-subcortical network including orbitofrontal and cingulate frontostriatal circuits together with the mesolimbic dopaminergic system that modulates their activity. Parkinson's disease (PD) provides a model for exploring this issue. By using an original emotion induction procedure, the present study examined to what extent subjective experience of emotion of PD patients at different stages of the disease was modulated by emotion in the same way as healthy individuals. A battery of film excerpts was used to elicit different emotional feelings (happiness, anger, fear, sadness, disgust, and neutral) in 15 newly diagnosed PD patients, 18 patients with advanced PD and 15 matched controls. The newly diagnosed patients were examined in two conditions: "on" and "off" dopaminergic medication. Participants reported the intensity of their emotional feelings on a scale consisting of 10 emotional categories. Results indicated that PD patients at different stages of the disease did not significantly differ from the controls in the self-reported emotional experience to the presented film excerpts. Moreover, analyses conducted within the newly diagnosed PD group (on-dopa vs. off-dopa conditions) indicated that the patients' emotional reactivity to the presented film excerpts was not significantly modulated by dopaminergic medication. These results thus question the possible role of dopaminergic pathways in subjective emotional experience, at least in this sample and in the context of emotion induction.
主观情感体验被认为依赖于一个包括眶额皮质和扣带回额前皮质-纹状体回路以及调节其活动的中脑边缘多巴胺能系统在内的大皮质-皮质下网络。帕金森病（PD）为探索这一问题提供了模型。通过使用原始的情感诱发程序，本研究考察了 PD 患者在疾病不同阶段的主观情感体验在多大程度上与健康个体一样受到情感的调节。一系列电影片段被用于诱发不同的情感感受（快乐、愤怒、恐惧、悲伤、厌恶和中性），共有 15 名新诊断的 PD 患者、18 名晚期 PD 患者和 15 名匹配的对照组参与。新诊断的患者在两种情况下接受检查：“开”和“关”多巴胺药物。参与者使用 10 个情感类别量表报告他们的情感感受强度。结果表明，处于疾病不同阶段的 PD 患者在对呈现的电影片段的自我报告情感体验方面与对照组没有显著差异。此外，在新诊断的 PD 组内（开多巴 vs. 关多巴条件）进行的分析表明，患者对呈现的电影片段的情绪反应不受多巴胺药物的显著调节。因此，这些结果质疑多巴胺能通路在主观情感体验中的可能作用，至少在本研究样本和情感诱发的背景下是如此。
