Department of Biochemical Engineering, Graduate School of Science and Technology, Yamagata University, Yonezawa, Yamagata 992-8510, Japan.
Bioorg Med Chem Lett. 2011 Aug 15;21(16):4865-8. doi: 10.1016/j.bmcl.2011.06.026. Epub 2011 Jul 7.
Solid phase synthesis of the cyclic depsipeptides of callipeltin B analogues and evaluation of cytotoxicity of synthetic peptides are described. We attempted to synthesize cyclic depsipeptides via the esterification or the amide bond formation for cyclization steps. In the assay of synthetic peptides, the linear peptide (10) exhibited modest cytotoxicity against HeLa cells.
本文描述了环二肽类似物 Callipeltin B 的固相合成以及合成肽的细胞毒性评价。我们尝试通过酯化或酰胺键形成进行环化步骤来合成环二肽。在合成肽的测定中，线性肽（10）对 HeLa 细胞表现出适度的细胞毒性。
