miRNA 对 DNA 损伤的响应。
miRNA response to DNA damage.
机构信息
Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
出版信息
Trends Biochem Sci. 2011 Sep;36(9):478-84. doi: 10.1016/j.tibs.2011.06.002. Epub 2011 Jul 7.
Abstract
Faithful transmission of genetic material in eukaryotic cells requires not only accurate DNA replication and chromosome distribution but also the ability to sense and repair spontaneous and induced DNA damage. To maintain genomic integrity, cells undergo a DNA damage response using a complex network of signaling pathways composed of coordinate sensors, transducers and effectors in cell cycle arrest, apoptosis and DNA repair. Emerging evidence has suggested that miRNAs play a crucial role in regulation of DNA damage response. In this review, we discuss the recent findings on how miRNAs interact with the canonical DNA damage response and how miRNA expression is regulated after DNA damage.
摘要
真核细胞中遗传物质的忠实传递不仅需要准确的 DNA 复制和染色体分配，还需要感知和修复自发和诱导的 DNA 损伤的能力。为了维持基因组完整性，细胞通过一个由协调传感器、转导器和效应器组成的复杂信号通路网络在细胞周期停滞、细胞凋亡和 DNA 修复中进行 DNA 损伤反应。新出现的证据表明，miRNAs 在调控 DNA 损伤反应中起着至关重要的作用。在这篇综述中，我们讨论了最近关于 miRNAs 如何与经典的 DNA 损伤反应相互作用以及 DNA 损伤后 miRNA 表达如何调控的发现。
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