急性呼吸窘迫综合征的气道压力释放通气。

Airway pressure release ventilation in acute respiratory distress syndrome.

机构信息

Department of Surgery, Section of Trauma, Surgical Critical Care and Surgical Emergencies, Yale University School of Medicine, 330 Cedar Street, BB310, PO Box 208062, New Haven, CT 06520-8062, USA.

出版信息

Crit Care Clin. 2011 Jul;27(3):501-9. doi: 10.1016/j.ccc.2011.05.003.

DOI:10.1016/j.ccc.2011.05.003

PMID:21742214

Abstract

Airway pressure release ventilation (APRV) is an alternative mode of ventilation that is increasingly used in patients with acute respiratory failure, acute lung injury (ALI), and acute respiratory distress syndrome (ARDS). Animal and clinical studies have demonstrated that, compared with conventional ventilation, APRV has beneficial effects on lung recruitment, oxygenation, end-organ blood flow, pulmonary vasoconstriction, and sedation requirements. Further studies, however, are required to directly compare APRV to ARDSnet protocol ventilation, specifically in patients with ALI/ARDS, and to determine whether managing ALI/ARDS with APRV will also achieve mortality reduction.

摘要

气道压力释放通气（APRV）是一种替代通气模式，越来越多地用于急性呼吸衰竭、急性肺损伤（ALI）和急性呼吸窘迫综合征（ARDS）患者。动物和临床研究表明，与常规通气相比，APRV 对肺复张、氧合、终末器官血流、肺血管收缩和镇静需求有有益的影响。然而，需要进一步的研究来直接比较 APRV 与 ARDSnet 协议通气，特别是在 ALI/ARDS 患者中，并确定使用 APRV 治疗 ALI/ARDS 是否也能降低死亡率。