急性肺损伤中的生物标志物——标志着向前发展。
Biomarkers in acute lung injury--marking forward progress.
机构信息
Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University, Nashville, TN 37232-2650, USA.
出版信息
Crit Care Clin. 2011 Jul;27(3):661-83. doi: 10.1016/j.ccc.2011.04.001.
Abstract
This article reviews the state of the art regarding biomarkers for prediction, diagnosis, and prognosis in acute lung injury. Biomarkers and the goals of biomarker research are defined. Progress along 4 general routes is examined. First, the results of wide-ranging existing protein biomarkers are reported. Second, newer biomarkers awaiting or with strong potential for validation are described. Third, progress in the fields of genomics and proteomics is reported. Finally, given the complexity and number of potential biomarkers, the results of combining clinical predictors with protein and other biomarkers to produce better prognostic and diagnostic indices are examined.
摘要
本文回顾了用于预测、诊断和预后急性肺损伤的生物标志物的最新研究进展。定义了生物标志物和生物标志物研究的目标。检查了沿着 4 条一般路线取得的进展。首先，报告了广泛存在的现有蛋白质生物标志物的结果。其次，描述了等待验证或具有很强验证潜力的新型生物标志物。第三，报告了基因组学和蛋白质组学领域的进展。最后，鉴于潜在生物标志物的复杂性和数量众多，研究了将临床预测因子与蛋白质和其他生物标志物相结合以产生更好的预后和诊断指数的结果。
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