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Combining statins with interferon β in multiple sclerosis: think twice, it might not be all right.在多发性硬化症中联合使用他汀类药物和β干扰素:三思而后行,这可能并非万全之策。
Lancet Neurol. 2011 Aug;10(8):672-3. doi: 10.1016/S1474-4422(11)70153-3.
2
Simvastatin as add-on therapy to interferon β-1a for relapsing-remitting multiple sclerosis (SIMCOMBIN study): a placebo-controlled randomised phase 4 trial.辛伐他汀作为复发缓解型多发性硬化症(SIMCOMBIN 研究)的干扰素 β-1a 附加治疗:一项安慰剂对照随机 4 期试验。
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Spotlight on subcutaneous recombinant interferon-beta-1a (Rebif) in relapsing-remitting multiple sclerosis.皮下注射重组干扰素β-1a(利比)治疗复发缓解型多发性硬化症的研究聚焦
BioDrugs. 2005;19(5):323-5. doi: 10.2165/00063030-200519050-00005.
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Widespread urticaria due to intramuscular interferon beta-1a therapy for multiple sclerosis.多发性硬化症患者接受肌肉内注射干扰素 β-1a 治疗后出现广泛荨麻疹。
Neurol Sci. 2011 Apr;32(2):309-11. doi: 10.1007/s10072-010-0432-0. Epub 2010 Oct 2.
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[Interferons beta in patients with multiple sclerosis].[多发性硬化症患者中的β干扰素]
Zh Nevrol Psikhiatr Im S S Korsakova. 2005;105(7):54-5.
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Combination therapy with interferon beta-1a and doxycycline in multiple sclerosis: an open-label trial.干扰素β-1a与强力霉素联合治疗多发性硬化症:一项开放标签试验。
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Neurology. 2000 Oct 24;55(8):1231-3. doi: 10.1212/wnl.55.8.1231.
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Simvastatin treatment in patients with relapsing-remitting multiple sclerosis receiving interferon beta 1a: a double-blind randomized controlled trial.辛伐他汀治疗接受干扰素β1a 治疗的复发性缓解型多发性硬化症患者:一项双盲随机对照试验。
Mult Scler. 2010 Jul;16(7):848-54. doi: 10.1177/1352458510369147. Epub 2010 May 20.
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Combining beta interferon and atorvastatin may increase disease activity in multiple sclerosis.联合使用β-干扰素和阿托伐他汀可能会增加多发性硬化症的疾病活动度。
Neurology. 2009 Sep 29;73(13):1078; author reply 1078-9. doi: 10.1212/WNL.0b013e3181ab6e08.
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[The comparative study of efficacy and tolerability of intramuscular introduction of beta-interferon-1a in adults and adolescents with remitting multiple sclerosis].[成人和青少年缓解型多发性硬化症患者肌肉注射β-干扰素-1a的疗效和耐受性比较研究]
Zh Nevrol Psikhiatr Im S S Korsakova. 2012;112(2 Pt 2):98-103.

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Potential of Therapeutic Small Molecules in Apoptosis Regulation in the Treatment of Neurodegenerative Diseases: An Updated Review.治疗性小分子在神经退行性疾病治疗中对细胞凋亡调控的作用:最新综述。
Molecules. 2022 Oct 25;27(21):7207. doi: 10.3390/molecules27217207.
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The Evolving Mechanisms of Action of Glatiramer Acetate.醋酸格拉替雷作用机制的演变。
Cold Spring Harb Perspect Med. 2019 Feb 1;9(2):a029249. doi: 10.1101/cshperspect.a029249.
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Glatiramer acetate treatment negatively regulates type I interferon signaling.醋酸格拉替雷治疗对I型干扰素信号传导具有负向调节作用。
Neurol Neuroimmunol Neuroinflamm. 2015 Nov 9;2(6):e179. doi: 10.1212/NXI.0000000000000179. eCollection 2015 Dec.
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Therapeutic decisions in multiple sclerosis: moving beyond efficacy.多发性硬化症的治疗决策:超越疗效。
JAMA Neurol. 2013 Oct;70(10):1315-24. doi: 10.1001/jamaneurol.2013.3510.
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Interference with RhoA-ROCK signaling mechanism in autoreactive CD4+ T cells enhances the bioavailability of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis.干扰自身反应性 CD4+T 细胞中的 RhoA-ROCK 信号机制可提高实验性自身免疫性脑脊髓炎中 1,25-二羟维生素 D3 的生物利用度。
Am J Pathol. 2012 Sep;181(3):993-1006. doi: 10.1016/j.ajpath.2012.05.028. Epub 2012 Jul 13.
6
Randomized controlled trial of atorvastatin in clinically isolated syndrome: the STAyCIS study.阿托伐他汀治疗临床孤立综合征的随机对照试验:STAyCIS 研究。
Neurology. 2012 Apr 10;78(15):1171-8. doi: 10.1212/WNL.0b013e31824f7fdd. Epub 2012 Mar 28.

本文引用的文献

1
Simvastatin as add-on therapy to interferon β-1a for relapsing-remitting multiple sclerosis (SIMCOMBIN study): a placebo-controlled randomised phase 4 trial.辛伐他汀作为复发缓解型多发性硬化症(SIMCOMBIN 研究)的干扰素 β-1a 附加治疗:一项安慰剂对照随机 4 期试验。
Lancet Neurol. 2011 Aug;10(8):691-701. doi: 10.1016/S1474-4422(11)70144-2.
2
Simvastatin treatment in patients with relapsing-remitting multiple sclerosis receiving interferon beta 1a: a double-blind randomized controlled trial.辛伐他汀治疗接受干扰素β1a 治疗的复发性缓解型多发性硬化症患者:一项双盲随机对照试验。
Mult Scler. 2010 Jul;16(7):848-54. doi: 10.1177/1352458510369147. Epub 2010 May 20.
3
T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis.辅助性 T 细胞 1 型和 17 型决定干扰素-β在多发性硬化症和实验性脑脊髓炎中的疗效。
Nat Med. 2010 Apr;16(4):406-12. doi: 10.1038/nm.2110. Epub 2010 Mar 28.
4
Atorvastatin combined to interferon to verify the efficacy (ACTIVE) in relapsing-remitting active multiple sclerosis patients: a longitudinal controlled trial of combination therapy.阿托伐他汀联合干扰素验证(ACTIVE)在复发缓解型活跃多发性硬化症患者中的疗效:一项联合治疗的纵向对照试验。
Mult Scler. 2010 Apr;16(4):450-4. doi: 10.1177/1352458509358909. Epub 2010 Feb 11.
5
Combining beta interferon and atorvastatin may increase disease activity in multiple sclerosis.联合使用β-干扰素和阿托伐他汀可能会增加多发性硬化症的疾病活动度。
Neurology. 2008 Oct 28;71(18):1390-5. doi: 10.1212/01.wnl.0000319698.40024.1c. Epub 2008 Jun 4.
6
Oral high-dose atorvastatin treatment in relapsing-remitting multiple sclerosis.口服大剂量阿托伐他汀治疗复发缓解型多发性硬化症。
PLoS One. 2008 Apr 9;3(4):e1928. doi: 10.1371/journal.pone.0001928.
7
Type II monocytes modulate T cell-mediated central nervous system autoimmune disease.II型单核细胞调节T细胞介导的中枢神经系统自身免疫性疾病。
Nat Med. 2007 Aug;13(8):935-43. doi: 10.1038/nm1620. Epub 2007 Aug 5.
8
Immunomodulatory effect of combination therapy with lovastatin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside alleviates neurodegeneration in experimental autoimmune encephalomyelitis.洛伐他汀与5-氨基咪唑-4-甲酰胺-1-β-D-呋喃核糖苷联合治疗的免疫调节作用减轻实验性自身免疫性脑脊髓炎中的神经退行性变。
Am J Pathol. 2006 Sep;169(3):1012-25. doi: 10.2353/ajpath.2006.051309.
9
Immunomodulatory synergy by combination of atorvastatin and glatiramer acetate in treatment of CNS autoimmunity.阿托伐他汀与醋酸格拉替雷联合治疗中枢神经系统自身免疫性疾病的免疫调节协同作用
J Clin Invest. 2006 Apr;116(4):1037-44. doi: 10.1172/JCI25805. Epub 2006 Mar 16.
10
The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease.HMG-CoA还原酶抑制剂阿托伐他汀可促进Th2偏向并逆转中枢神经系统自身免疫性疾病中的麻痹状态。
Nature. 2002 Nov 7;420(6911):78-84. doi: 10.1038/nature01158.

Combining statins with interferon β in multiple sclerosis: think twice, it might not be all right.

作者信息

Zamvil Scott S, Steinman Lawrence

出版信息

Lancet Neurol. 2011 Aug;10(8):672-3. doi: 10.1016/S1474-4422(11)70153-3.

DOI:10.1016/S1474-4422(11)70153-3
PMID:21742557
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4106800/
Abstract
摘要