Amgen, 1201 Amgen Court West, Seattle, Washington 98119, USA.
Nat Rev Immunol. 2010 Feb;10(2):89-102. doi: 10.1038/nri2691. Epub 2010 Jan 18.
Over recent years it has become increasingly clear that innate immune responses can shape the adaptive immune response. Among the most potent molecules of the innate immune system are the interleukin-1 (IL-1) family members. These evolutionarily ancient cytokines are made by and act on innate immune cells to influence their survival and function. In addition, they act directly on lymphocytes to reinforce certain adaptive immune responses. This Review provides an overview of both the long-established and more recently characterized members of the IL-1 family. In addition to their effects on immune cells, their involvement in human disease and disease models is discussed.
近年来，越来越明显的是，先天免疫反应可以塑造适应性免疫反应。先天免疫系统中最有效的分子之一是白细胞介素-1（IL-1）家族成员。这些进化上古老的细胞因子由先天免疫细胞产生并作用于它们，以影响它们的存活和功能。此外，它们还直接作用于淋巴细胞，以加强某些适应性免疫反应。这篇综述概述了 IL-1 家族中既有长期确立的成员，也有最近被描述的成员。除了它们对免疫细胞的影响外，还讨论了它们在人类疾病和疾病模型中的参与。
