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鼻窦疾病患者的嗅球体积

Olfactory bulb volume in patients with sinonasal disease.

作者信息

Rombaux Philippe, Potier Helene, Bertrand Bernard, Duprez Thierry, Hummel Thomas

机构信息

Department of Otorhinolaryngology, Cliniques Universitaires Saint Luc, Brussels, Belgium.

出版信息

Am J Rhinol. 2008 Nov-Dec;22(6):598-601. doi: 10.2500/ajr.2008.22.3237.

Abstract

BACKGROUND

The aim of this study was to assess the volume of the olfactory bulb (OB) in patients with chronic rhinosinusitis (without nasal polyposis at the endoscopic evaluation) and to evaluate the correlation between this measure and the degree of sinonasal inflammation.

METHODS

Patients with sinonasal disease (SND; n = 22) were compared with healthy controls (n = 16) using orthonasal and retronasal olfactory test results and OB volumes measurement calculated by planimetric manual contouring using standardized methods. The Lund-Mackay score (originally described for CT scan) was also used to gauge sinonasal inflammation (SND score).

RESULTS

The two groups were not significantly different in terms of age or distribution of sex. Patients had significantly higher right- and left-sided SND scores than controls. There was no significant group difference between patients and controls with regard to OB volume. However, patients with an SND score < or =12 had larger OB volumes than patients with higher SND scores (p < 0.001). Even when controlling for the subjects' age, a significant correlation was present between OB volume and SND score (r = -0.52; p = 0.001) with smaller OB volumes being associated with a higher degree of sinonasal pathology.

CONCLUSION

OB volume correlated with the SND score, which is an indicator of the degree of sinonasal inflammation. SND patients with a slight decrease or even normal olfactory function may already exhibit changes in their OB volume. This study also seems to emphasize the idea that OB volume changes are more sensitive to subtle changes in the olfactory system than results from psychophysical testing.

摘要

背景

本研究旨在评估慢性鼻窦炎患者(内镜评估无鼻息肉)嗅球(OB)的体积,并评估该测量值与鼻窦炎症程度之间的相关性。

方法

使用经鼻和鼻后嗅觉测试结果以及通过标准化方法的平面手动轮廓测量计算的OB体积,将鼻窦疾病(SND;n = 22)患者与健康对照者(n = 16)进行比较。还使用Lund-Mackay评分(最初用于CT扫描)来衡量鼻窦炎症(SND评分)。

结果

两组在年龄或性别分布方面无显著差异。患者的右侧和左侧SND评分显著高于对照组。患者和对照组在OB体积方面无显著组间差异。然而,SND评分≤12的患者比SND评分较高的患者具有更大的OB体积(p < 0.001)。即使在控制受试者年龄后,OB体积与SND评分之间仍存在显著相关性(r = -0.52;p = 0.001),较小的OB体积与更高程度的鼻窦病变相关。

结论

OB体积与SND评分相关,SND评分是鼻窦炎症程度的指标。嗅觉功能略有下降甚至正常的SND患者可能已经表现出OB体积的变化。本研究似乎还强调了这样一种观点,即OB体积变化对嗅觉系统的细微变化比心理物理学测试结果更敏感。

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