School of Chemical Sciences, The University of Auckland, 23 Symonds St, Auckland, 1142, New Zealand.
Org Biomol Chem. 2011 Sep 7;9(17):5897-907. doi: 10.1039/c1ob05777d. Epub 2011 Jul 8.
Dehydrotryptophan and its derivatives are non-proteinogenic amino acids commonly found in peptide-based natural products produced by microorganisms, marine organisms and plants. These non-proteinogenic amino acids are found in secondary metabolites and are formed by post translational modification processes. Although comprehensive reviews on the synthesis of dehydroamino acids are available, this perspective focuses solely on methods to synthesise the dehydrotryptophan-containing segment of naturally occurring peptides, amino acids and their derivatives.
去氢色氨酸及其衍生物是非蛋白质氨基酸，常见于微生物、海洋生物和植物产生的基于肽的天然产物中。这些非蛋白质氨基酸存在于次生代谢物中，是通过翻译后修饰过程形成的。虽然已经有关于脱氢氨基酸合成的综合评论，但本观点仅关注于合成天然存在的肽、氨基酸及其衍生物中含去氢色氨酸片段的方法。
