猪钙释放通道基因（恶性高热位点的一个候选基因）定位于6号染色体的6p11----q21区段。
Assignment of the porcine calcium release channel gene, a candidate for the malignant hyperthermia locus, to the 6p11----q21 segment of chromosome 6.
作者信息
Harbitz I, Chowdhary B, Thomsen P D, Davies W, Kaufmann U, Kran S, Gustavsson I, Christensen K, Hauge J G
机构信息
Department of Biochemistry, Norwegian College of Veterinary Medicine, Oslo.
出版信息
Genomics. 1990 Oct;8(2):243-8. doi: 10.1016/0888-7543(90)90278-3.
Several studies point to the possibility that malignant hyperthermia (MH) in pigs is caused by a defect in the calcium release channel (CRC) of skeletal muscle sarcoplasmic reticulum. The locus for MH is closely linked to the glucosephosphate isomerase (GPI) locus, near the centromere of chromosome 6. We demonstrate synteny of the genes for CRC and GPI using somatic cell hybrid lines, and assign the CRC gene to chromosome 6p11----q21 by in situ hybridization.
多项研究表明，猪的恶性高热（MH）可能是由骨骼肌肌浆网钙释放通道（CRC）缺陷引起的。MH的基因位点与6号染色体着丝粒附近的葡萄糖磷酸异构酶（GPI）基因位点紧密连锁。我们利用体细胞杂交系证明了CRC和GPI基因的同线性，并通过原位杂交将CRC基因定位于6号染色体p11----q21。
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