Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science & Technology (JUST), Irbid, Jordan.
Int J Clin Pharm. 2011 Apr;33(2):229-36. doi: 10.1007/s11096-011-9479-0. Epub 2011 Jan 28.
The purpose of this study is to investigate the effectiveness of introducing clinical pharmacy services in achieving goal lipid profile in dyslipidemia patients in North of Jordan. Setting the study was carried out in a primary care facility in North of Jordan.
One hundred fifty two dyslipidemia patients were randomized into intervention and control groups and followed for 6 months period. Intervention group patients were followed intensively by a clinical pharmacist who worked closely with physicians in controlling lipid profiles according to the third edition of recommendations by The National Cholesterol Education Program Adult Treatment Panel, control group patients were provided with standard medical care. Main outcome measure percent of patients at their low density lipoprotein cholesterol target in the intervention group compared to percent of patients at their low density lipoprotein cholesterol target in the control group by the end of the study.
One hundred twenty five patients completed the study duration. After 6 months, 94.5% of intervention group patients and 71.2 % of control group patients reached their goal low density lipoprotein cholesterol levels (P value < 0.001, Pearson Chi-Square test) compared to 24.7 and 28.8% respectively at baseline. Majority of pharmacist recommendations (90.4%) were followed by physicians and overall lipid lowering agents use was increased to 91.8% in intervention group patients and 86.5% in control group patients compared to 69.9 and 78.8% respectively at baseline.
Implementing clinical pharmacy services in Jordan has improved the lipid profiles of dyslipidemic patients.
本研究旨在探讨在约旦北部引入临床药学服务对血脂异常患者实现目标血脂谱的效果。研究地点设在约旦北部的一家初级保健机构。
152 名血脂异常患者被随机分为干预组和对照组，并随访 6 个月。干预组患者由临床药师进行强化随访，药师与医生密切合作，根据美国国家胆固醇教育计划成人治疗专家组的第三版建议控制血脂谱，对照组患者接受标准医疗护理。主要观察指标为干预组患者在研究结束时达到低密度脂蛋白胆固醇目标的比例与对照组患者达到低密度脂蛋白胆固醇目标的比例。
125 名患者完成了研究。6 个月后，干预组 94.5%的患者和对照组 71.2%的患者达到了目标低密度脂蛋白胆固醇水平（P 值<0.001，Pearson Chi-Square 检验），而基线时分别为 24.7%和 28.8%。大多数药师建议（90.4%）都得到了医生的采纳，与基线时的 69.9%和 78.8%相比，干预组患者和对照组患者的降脂药物总使用率分别增加到 91.8%和 86.5%。
在约旦实施临床药学服务改善了血脂异常患者的血脂谱。
