Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu-city, Mie, Japan.
J Surg Oncol. 2011 Dec;104(7):771-5. doi: 10.1002/jso.22006. Epub 2011 Jul 8.
There are very few reports regarding the impact of the symptom that caused patients to consult a doctor and the symptom-to-diagnosis delay on survival for soft tissue sarcoma patients. The purpose of this study is to investigate whether symptom-treatment delay are associated with the presence of metastasis at diagnosis, overall survival and distant metastasis-free survival in primary soft tissue sarcomas.
This study retrospectively reviewed the medical records of 100 newly diagnosed patients with primary soft tissue sarcoma referred to our hospital.
Eighteen of 100 sarcoma patients had distant metastases at diagnosis. A multivariate logistic regression analysis revealed that tumor size, tumor site, and the interval between the onset of the initial symptom and the first consultation to our hospital were all found to be significant predictors of distant metastases at diagnosis. The patients (n = 48) who were treated within the first 6 months from the onset of the initial symptom showed significantly better cumulative overall survival rate than those (n = 34) who were diagnosed more than 6 months (5-years: 77.0% vs. 59.7%).
These results suggest that a shorter delay may have a beneficial effect on treatment options and outcome, improving survival in some sarcoma patients.
关于导致患者就诊的症状以及症状至诊断的延误对软组织肉瘤患者生存的影响，相关报告非常少。本研究旨在探讨原发性软组织肉瘤患者的症状-治疗延误是否与诊断时转移的存在、总生存率和无远处转移生存率相关。
本研究回顾性分析了 100 例新诊断的原发性软组织肉瘤患者的病历，这些患者均被转诊至我院。
100 例肉瘤患者中有 18 例在诊断时发生远处转移。多变量逻辑回归分析显示，肿瘤大小、肿瘤部位和初始症状出现至首次就诊我院的间隔时间均是诊断远处转移的显著预测因子。与诊断超过 6 个月的患者（n=34）相比，在初始症状出现后 6 个月内接受治疗的患者（n=48）的累积总生存率显著提高（5 年：77.0%比 59.7%）。
这些结果表明，较短的延误可能对治疗选择和结果产生有益影响，改善某些肉瘤患者的生存。
