Division of Gastroenterology, University of Calgary, Calgary, Alberta, Canada.
Inflamm Bowel Dis. 2011 Aug;17(8):1792-9. doi: 10.1002/ibd.21511. Epub 2010 Nov 28.
In the last several years there has been an explosion in the discovery of inflammatory bowel disease (IBD) susceptibility genes; however, similar advances in identifying and defining environmental risk factors associated with IBD have lagged behind. Moreover, many studies that have explored the same or similar environmental risk factors of IBD have demonstrated disparate results and come to conflicting conclusions. In order for the field to move forward, it is important to understand and resolve why these differences exist. This significant heterogeneity has blurred the identification of the fundamental environmental determinants of IBD. The purpose of this review article is to explore the factors that have likely contributed to the heterogeneity among observational studies of environmental risk factors in IBD. In doing so, it is hoped that methodological standardization may lead to consistent environmental associations.
在过去的几年中，人们发现了炎症性肠病（IBD）易感性基因的大量涌现；然而，在确定和定义与 IBD 相关的环境风险因素方面，类似的进展却落后了。此外，许多研究都探讨了相同或相似的 IBD 环境风险因素，但结果却大相径庭，得出的结论也相互矛盾。为了推动该领域的发展，了解并解决这些差异存在的原因非常重要。这种显著的异质性使得 IBD 的基本环境决定因素的识别变得模糊不清。本文的目的是探讨可能导致 IBD 环境风险因素观察性研究中异质性的因素。希望通过方法学的标准化，可以得出一致的环境关联。
