Danpanichkul Pojsakorn, Suparan Kanokphong, Arayakarnkul Suchapa, Jaroenlapnopparat Aunchalee, Polpichai Natchaya, Fangsaard Panisara, Kongarin Siwanart, Srisurapanont Karan, Sukphutanan Banthoon, Wanchaitanawong Wasuwit, Kanjanakot Yatawee, Pupaibool Jakrapun, Duangsonk Kwanjit, Kochhar Gursimran Singh, Wijarnpreecha Karn
Immunology Unit, Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
J Clin Med. 2023 Aug 6;12(15):5142. doi: 10.3390/jcm12155142.
Inflammatory bowel disease (IBD), once thought to impact younger individuals, now manifests in approximately 10% of patients over 65, characterized by a heightened vulnerability to complications and greater diagnostic intricacies than conventional cases. However, comprehensive global epidemiological data regarding elderly-onset IBD are currently insufficient. Our study addresses this critical gap by analyzing trends in elderly-onset IBD over a decade, encompassing the estimation of annual frequencies and age-standardized rates of elderly-onset IBD burden for both genders, stratifying the data by geographical and sociodemographic factors. Our research highlights a notable increase in the proportion of elderly-onset IBD, constituting around 13% of all IBD cases. We observed a rising incidence in males, contrasted by a decreasing trend in females. The highest surge in incidence rates was seen in the Western Pacific region in both genders, but the highest burden was observed in America. Countries with high sociodemographic index (SDI) carried the greatest burden of elderly-onset IBD, while countries with low SDI had the least. The mortality and disability-adjusted life years (DALYs) rates trend downward in most regions. This study underscores an increasing incidence and proportion of IBD, particularly in elderly-onset IBD, particularly in males. While mortality and DALYs are decreasing in most regions, the overall burden remains highest in America and high-SDI countries. Effective public health interventions and comprehensive studies are required to tackle this mounting burden.
炎症性肠病（IBD）曾被认为主要影响年轻人，现在约10%的65岁以上患者患有该病，其特点是比传统病例更容易出现并发症且诊断更为复杂。然而，目前关于老年发病IBD的全球综合流行病学数据不足。我们的研究通过分析十年来老年发病IBD的趋势来填补这一关键空白，包括估计老年发病IBD负担的年度发病率和年龄标准化率，按地理和社会人口因素对数据进行分层。我们的研究突出了老年发病IBD比例的显著增加，约占所有IBD病例的13%。我们观察到男性发病率上升，而女性呈下降趋势。男女发病率上升幅度最大的是西太平洋地区，但负担最重的是美洲。社会人口指数（SDI）高的国家老年发病IBD负担最重，而SDI低的国家负担最轻。大多数地区的死亡率和伤残调整生命年（DALYs）率呈下降趋势。这项研究强调了IBD发病率和比例的增加，特别是在老年发病IBD中，尤其是男性。虽然大多数地区的死亡率和DALYs在下降，但美国和高SDI国家的总体负担仍然最高。需要有效的公共卫生干预措施和全面的研究来应对这一日益增加的负担。
