Neu J, Wu-Wang C Y
Department of Pediatrics, University of Florida College of Medicine, Gainesville 32610.
Prostaglandins Leukot Essent Fatty Acids. 1990 Sep;41(1):63-6. doi: 10.1016/0952-3278(90)90132-5.
While prostaglandins of the E series are known to affect several small intestinal functions, their cellular mechanisms are poorly understood. The purposes of this study were to determine if there are developmental differences in the binding of PGE1, to the small intestinal enterocyte and if this binding may be affected by glucocorticoids, which are known to accelerate maturation of the small intestine. Small intestinal binding of prostaglandin E1 was significantly higher in adult rats when compared to postweaned (25-day-old) and preweaned (15- to 17-day-old) rats. Hydrocortisone administration for two days had no effect on the binding of prostaglandin E1 in either preweaned of adult rats. We conclude that a developmental change occurs in prostaglandin E1 binding to the plasma membrane of the rat small intestinal enterocyte during maturation. This binding is not affected by the administration of hydrocortisone.
虽然已知E系列前列腺素会影响多种小肠功能，但其细胞机制却鲜为人知。本研究的目的是确定前列腺素E1与小肠肠上皮细胞的结合是否存在发育差异，以及这种结合是否会受到已知可加速小肠成熟的糖皮质激素的影响。与断奶后（25日龄）和断奶前（15至17日龄）的大鼠相比，成年大鼠小肠对前列腺素E1的结合显著更高。对断奶前和成年大鼠连续两天给予氢化可的松对前列腺素E1的结合均无影响。我们得出结论，在成熟过程中，大鼠小肠肠上皮细胞质膜上前列腺素E1的结合发生了发育变化。这种结合不受氢化可的松给药的影响。
