Institute of Psychiatry, King's College London, London, UK.
J Affect Disord. 2011 Nov;134(1-3):483-7. doi: 10.1016/j.jad.2011.05.057. Epub 2011 Jul 13.
Reduced hippocampal volume has been consistently observed in major depressive disorder. Hippocampal volume loss is particularly evident in patients with recurrent and chronic depression. However, the reports in first episode depression have been mixed.
We performed a random effects meta-analysis to establish whether hippocampal atrophy exists from disease onset. We included magnetic resonance imaging studies of hippocampal volume in patients with first episode major depressive disorder and matched healthy controls.
A total of 7 studies met our inclusion and exclusion criteria, representing independent observations in a total sample of 191 patients and 282 healthy controls. The cumulative analysis revealed hippocampal volume loss in patients with first episode depression relative to controls in both the left (standardised mean difference, SMD = -0.41, 95% Confidence Interval: [-0.78;-0.03], z = -2.14, p = 0.0321) and right (SMD = -0.53[-0.98;-0.09], z = -2.38, p = 0.0173) hippocampi. The average volume reduction was -4.0% in the left and -4.5% in the right hippocampus.
Hippocampal volume loss in first episode depression is consistent with a neurodevelopmental model of depression, advocating hippocampal structure as a potential diagnostic neurobiomarker for depression.
在重度抑郁症患者中，海马体体积减小的现象一直存在。海马体体积的损失在反复发作和慢性抑郁症患者中尤为明显。然而，首次发作的抑郁症患者的报告结果却存在差异。
我们进行了一项随机效应荟萃分析，以确定从疾病发作开始是否存在海马体萎缩。我们纳入了首发重度抑郁症患者和匹配的健康对照组的磁共振成像海马体体积研究。
共有 7 项研究符合我们的纳入和排除标准，代表了总共 191 名患者和 282 名健康对照者的独立观察结果。累积分析显示，与对照组相比，首发抑郁症患者的左（标准化均数差值，SMD = -0.41，95%置信区间：[-0.78;-0.03]，z = -2.14，p = 0.0321）和右（SMD = -0.53[-0.98;-0.09]，z = -2.38，p = 0.0173）海马体体积减小。左海马体的平均体积减少了-4.0%，右海马体的平均体积减少了-4.5%。
首发抑郁症患者的海马体体积减小与抑郁症的神经发育模型一致，主张海马体结构作为抑郁症的潜在诊断神经生物标志物。
