Endocrine Research Center, Research Institute of Endocrine Sciences, Shahid Beheshti University, (M.C.), Tehran, Iran.
J Endocrinol Invest. 2011 Jun;34(6):431-3. doi: 10.1007/BF03346708.
Thyroid hormone deficiency may affect human speech and voice. The aim of this study was to evaluate speech variables in patients with hypothyroidism.
A case control study.
One hundred and twenty patients, 106 women and 14 men with symptoms and signs of thyroid failure; the diagnosis was confirmed by serum T4<4.5 μg/dl and serum TSH>10 mU/l. Eighty-eight normal subjects, 78 women and 10 men, age-, sex-, and smoking status- matched, served as controls.
All symptoms and signs of hypothyroidism were recorded. Serum T4, T3, and TSH concentrations were measured. Speech parameters were analyzed by the Visipitch III system model 3900 and multidimensional voice program software and compared to a group of normal subjects with no thyroid disease.
Mean age was 35.9±11.4 yr. Dryness in larynx and pharynx, dyspnea, and sensation of lump in the throat were reported by 53.49 and 43% of patients, respectively. Fundamental frequency, voice turbulence index, and soft phonation index were significantly different from control values. There was positive correlation between TSH concentration and variation in fundamental frequency and prevalence of voice disorders (37.2±31.2 vs 23.9±25.8 mU/l, p<0.003).
Frequent speech disturbances occur in patients with primary hypothyroidism.
甲状腺激素缺乏可能会影响人类的言语和声音。本研究旨在评估甲状腺功能减退症患者的言语变量。
病例对照研究。
120 例患者，106 名女性和 14 名男性，有甲状腺功能减退的症状和体征；诊断依据为血清 T4<4.5μg/dl 和血清 TSH>10mU/l。88 名正常对照者，78 名女性和 10 名男性，年龄、性别和吸烟状况匹配，作为对照组。
记录所有甲状腺功能减退的症状和体征。测量血清 T4、T3 和 TSH 浓度。通过 Visipitch III 系统模型 3900 和多维语音程序软件分析语音参数，并与一组无甲状腺疾病的正常对照组进行比较。
平均年龄为 35.9±11.4 岁。53.49%和 43%的患者分别报告有咽喉干燥和咽部不适、呼吸困难和喉咙有异物感。基频、嗓音湍流指数和柔和发声指数与对照组有显著差异。TSH 浓度与基频变化和嗓音障碍的患病率呈正相关（37.2±31.2 vs 23.9±25.8mU/l，p<0.003）。
原发性甲状腺功能减退症患者常出现言语障碍。
