Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, Changhua, Taiwan.
Eur Arch Otorhinolaryngol. 2012 Mar;269(3):959-63. doi: 10.1007/s00405-011-1685-9. Epub 2011 Jul 12.
The objectives of this paper are to evaluate the heterogeneity of magnetic resonance imaging (MRI)-derived tumor thickness within tumors of the same T4a-staged tongue carcinoma and to elucidate the effects of tumor thickness on treatment outcomes. A sequential and prospectively maintained head and neck cancer database was retrospectively searched for newly diagnosed tongue carcinoma treated with surgery between 2003 and 2006. Fifty-eight patients with newly diagnosed T4a-staged tongue carcinoma were included in this study. Tumor thickness was obtained from preoperative magnetic resonance imaging. The mean MRI-derived tumor thickness was 22.29 mm. The patients with long tumor thickness (>26 mm) were associated with a significantly poor disease-specific survival (P = 0.015). The 2-year disease-specific survival rates were 72% in patients with short tumor thickness and only 27% in patients with long tumor thickness within the same T4a-staged disease. A substantial variation in MRI-derived tumor thickness was present within the same T4a-staged tongue carcinoma, and tumor thickness represented an important prognostic factor.
本文旨在评估同一 T4a 期舌癌肿瘤内磁共振成像（MRI）得出的肿瘤厚度的异质性，并阐明肿瘤厚度对治疗结果的影响。我们对 2003 年至 2006 年间接受手术治疗的新诊断舌癌的连续和前瞻性维护的头颈部癌症数据库进行了回顾性搜索。本研究纳入了 58 例新诊断的 T4a 期舌癌患者。肿瘤厚度从术前 MRI 中获得。平均 MRI 得出的肿瘤厚度为 22.29mm。肿瘤厚度较长（>26mm）的患者疾病特异性生存率显著较差（P=0.015）。肿瘤厚度较短的患者 2 年疾病特异性生存率为 72%，而同一 T4a 期疾病中肿瘤厚度较长的患者仅为 27%。同一 T4a 期舌癌内 MRI 得出的肿瘤厚度存在很大差异，肿瘤厚度是一个重要的预后因素。
