铜（三唑 - 5 - 基）甲胺配合物负载于MCM - 41上：通过1,5 - 烯炔的6 - 外向环化反应合成含吡啶的拟肽。
Copper (triazole-5-yl)methanamine complexes onto MCM-41: the synthesis of pyridine-containing pseudopeptides through the 6--dig cyclization of 1,5-enynes.
作者信息
Akbarikalani Neda, Amiri Kamran, Al-Harrasi Ahmed, Balalaie Saeed
机构信息
Peptide Chemistry Research Center, K. N. Toosi University of Technology P. O. Box 15875-4416 Tehran Iran
Natural and Medical Sciences Research Center, University of Nizwa P. O. Box 33, Postal Code 616, Birkat Al Mauz Nizwa Sultanate of Oman.
出版信息
RSC Adv. 2020 Mar 12;10(18):10577-10583. doi: 10.1039/c9ra10885h. eCollection 2020 Mar 11.
An efficient approach for the synthesis of immobilized copper (triazole-5-yl)methanamine complexes onto MCM-41 (Cu@TZMA@MCM-41), as a novel recyclable nanocatalyst, is described. This nanocatalyst was used for the synthesis of pyridine-containing pseudopeptides through a sequential Ugi/nucleophilic addition/1,5-enyne cyclization reaction and elicited good-to-excellent yields. The nanocatalyst was fully characterized by SEM, EDS, TEM, BET, ICP-OES, TGA, and XRD techniques. Furthermore, the catalyst was recovered by simple filtration and could be used for at least 5 cycles without significant loss of activity.
描述了一种将固定化铜（三唑-5-基）甲胺配合物合成到MCM-41（Cu@TZMA@MCM-41）上的有效方法，该材料作为一种新型可回收纳米催化剂。这种纳米催化剂用于通过连续的乌吉反应/亲核加成/1,5-烯炔环化反应合成含吡啶的拟肽，并获得了良好到优异的产率。通过扫描电子显微镜（SEM）、能谱仪（EDS）、透射电子显微镜（TEM）、比表面积分析仪（BET）、电感耦合等离子体发射光谱仪（ICP-OES）、热重分析仪（TGA）和X射线衍射仪（XRD）技术对该纳米催化剂进行了全面表征。此外，通过简单过滤即可回收该催化剂，并且可以重复使用至少5次而活性无明显损失。
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