评价四种快速诊断检测方法在韩国诊断间日疟原虫中的应用。
Evaluation of four rapid diagnostic tests for the diagnosis of Plasmodium vivax in Korea.
机构信息
Department of Laboratory Medicine, Korea University, Seoul, Korea.
出版信息
Trop Med Int Health. 2011 Nov;16(11):1427-31. doi: 10.1111/j.1365-3156.2011.02846.x. Epub 2011 Jul 12.
OBJECTIVE
To evaluate 4 rapid malaria diagnostic kits (RDTs) in Korea: OptiMAL test, SD BIOLINE Malaria Ag P.f/Pan test, Humasis Malaria P.f/Pan antigen test and CareStart Malaria Pf/Pv Combo test.
METHODS
Hundred malaria patients with Plasmodium vivax (P. vivax) and 100 healthy volunteers were recruited. The results from earlier four RDTs were compared with the reference standard, the Giemsa-stained traditional microscopic diagnosis.
RESULTS
Compared with the reference standard, the sensitivity and specificity for Plasmodium vivax were 92.7 and 100% for SD BIOLINE Malaria Ag P.f/Pan; and 94.6% and 100% for OptiMAL; 95.5% and 100% for both Humasis Malaria P.f/Pan antigen test and CareStart Malaria Pf/Pv Combo test.
CONCLUSION
The performances of all four malaria RDT kits were acceptable, although Humasis Malaria P.f/Pan antigen test and CareStart Malaria Pf/Pv Combo test gave superior performances with ROK isolates.
目的
评估韩国的 4 种快速疟疾诊断试剂盒（RDTs）：OptiMAL 测试、SD BIOLINE 疟疾 Ag P.f/Pan 测试、Humasis 疟疾 P.f/Pan 抗原测试和 CareStart 疟疾 Pf/Pv 联合测试。
方法
招募了 100 名患有间日疟原虫（P. vivax）的疟疾患者和 100 名健康志愿者。将前四种 RDT 的结果与参考标准（吉姆萨染色传统显微镜诊断）进行比较。
结果
与参考标准相比，SD BIOLINE 疟疾 Ag P.f/Pan 的灵敏度和特异性分别为 92.7%和 100%；OptiMAL 的灵敏度和特异性分别为 94.6%和 100%；Humasis 疟疾 P.f/Pan 抗原测试和 CareStart 疟疾 Pf/Pv 联合测试的灵敏度和特异性均为 95.5%和 100%。
结论
尽管 Humasis 疟疾 P.f/Pan 抗原测试和 CareStart 疟疾 Pf/Pv 联合测试对韩国分离株的表现更优，但所有 4 种疟疾 RDT 试剂盒的性能均可接受。
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