Godoy Pere, Pumarola Tomàs, Martínez Anna, Torner Núria, Rodés Anna, Carmona Glòria, Ciruela Pilar, Caylà Joan, Tortajada Cecilia, Domínguez Angela, Plasència Antoni
Departamento de Salud, Generalidad de Cataluña, C/Alcalde Rovira Roure 2, Lleida.
Rev Esp Salud Publica. 2011 Jan-Feb;85(1):37-45. doi: 10.1590/S1135-57272011000100005.
Pandemics require an assessment of its severity. The objective was to determine the characteristics of pandemic influenza in Catalonia.
We conducted a surveillance study on the incidence of ILI and severe cases between June 2009 and May 2010. A network of 55 doctors reported influenza-like illness and collected nasopharyngeal swabs. The severity of the pandemic was assessed through severe cases confirmed.We calculated the lethality and incidence rates and mortality. The differences are studied with the relative risk (RR) with confidence intervals (CI) of 95%.
The incidence of ILI was much higher in the 5 to 14 and from 0 to 4 years old (1227.8 and 1048.4, respectively, in the week of maximum incidence). Of positive samples, 52.4% (477/916) were positive for influenza virus and the majority, 456 (95.6%) were the pandemic influenza virus (H1N1) 2009.The incidence of severe cases was 10.3 per 10(5) and was higher in children (14,5) and adults under 65 years (10,2) (p < 0.0001). Overall mortality was 0.7 per 10(5) and was also higher in children and adults under 65 but the differences were not statistically significant. The fatality rate was estimated at 0.03% and was much higher in the 15 to 44 years (0,03%) (RR = 3.1, 95% CI 1.2 to 8.3), 45 to 64 years (0,11%) (RR = 11.9 95% CI 4.3 to 32.7) and over 64 years (0,73%) (RR = 79.6, 95% CI 25.3 to 250.9) compared to group 5 to 14 years (0,01%).
The incidence of severe hospitalized cases was similar to or lower than that observed in the southern hemisphere. The lower risk of hospitalization in people over 64 years suggests the relative protection of this age group against the pandemic virus.
大流行需要对其严重程度进行评估。目的是确定加泰罗尼亚大流行性流感的特征。
我们对2009年6月至2010年5月期间流感样疾病（ILI）和重症病例的发病率进行了一项监测研究。一个由55名医生组成的网络报告流感样疾病并采集鼻咽拭子。通过确诊的重症病例评估大流行的严重程度。我们计算了致死率、发病率和死亡率。采用相对危险度（RR）及95%可信区间（CI）研究差异。
5至14岁以及0至4岁年龄组的ILI发病率要高得多（发病率最高的那周分别为1227.8和1048.4）。在阳性样本中，52.4%（477/916）的流感病毒检测呈阳性，其中大多数，即456例（95.6%）为2009年大流行性流感病毒（H1N1）。重症病例的发病率为每10万人中10.3例，在儿童（14.5）和65岁以下成年人（10.2）中更高（p<0.0001）。总体死亡率为每10万人中0.7例，在儿童和65岁以下成年人中也更高，但差异无统计学意义。病死率估计为0.03%，在15至44岁年龄组（0.03%）（RR=3.1，95%CI为1.2至8.3）、45至64岁年龄组（0.11%）（RR=11.9，95%CI为4.3至32.7）以及64岁以上年龄组（0.73%）（RR=79.6，95%CI为25.3至250.9）中比5至14岁年龄组（0.01%）高得多。
重症住院病例的发病率与南半球观察到的发病率相似或更低。64岁以上人群住院风险较低表明该年龄组对大流行病毒有相对的保护作用。
