Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
J Biophotonics. 2011 Aug;4(7-8):471-81. doi: 10.1002/jbio.201100048. Epub 2011 Jul 13.
The future of endoscopy will be dictated by rapid technological advances in the development of light sources, optical fibers, and miniature scanners that will allow for images to be collected in multiple spectral regimes, with greater tissue penetration, and in three dimensions. These engineering breakthroughs will be integrated with novel molecular probes that are highly specific for unique proteins to target diseased tissues. Applications include early cancer detection by imaging molecular changes that occur before gross morphological abnormalities, personalized medicine by visualizing molecular targets specific to individual patients, and image guided therapy by localizing tumor margins and monitoring for recurrence.
内窥镜的未来将由光源、光纤和微型扫描仪的快速技术进步所决定，这些进步将使我们能够在多个光谱范围内以更高的组织穿透性和三维方式采集图像。这些工程突破将与新型分子探针相结合，这些探针对独特的蛋白质具有高度特异性，可用于靶向病变组织。应用包括通过成像在大体形态异常发生之前发生的分子变化来早期检测癌症，通过可视化针对个体患者的特定分子靶标来进行个性化医疗，以及通过定位肿瘤边缘和监测复发来进行图像引导治疗。
