Kute Vivek, Goplani K R, Godara S M, Shah P R, Vanikar A V, Trivedii H L
Department of Nephrology and Clinical Transplantation, Dr H L Trivedi Institute of Transplantation Sciences (ITS) Ahmedabad 380016, Gujarat, India.
J Assoc Physicians India. 2011 Jan;59:49-51.
Kidney transplant recipients are at a high risk for H1N1 infection associated complications during the current pandemic. Prevention of infection by immunization, together with early recognition and prompt antiviral treatment are critical. Post-exposure prophylaxis of H1N1 with oseltamivir was safe, effective and well tolerated to prevent H1N1 influenza A virus infection in newly transplanted renal allograft recipient receiving triple immunosuppression without any interaction with tacrolimus level. Oseltamivir was effective for post-exposure prophylaxis of H1N1 in close contact.
在当前大流行期间，肾移植受者发生甲型H1N1流感感染相关并发症的风险很高。通过免疫接种预防感染，以及早期识别和及时进行抗病毒治疗至关重要。对接受三联免疫抑制的新移植肾移植受者，使用奥司他韦进行甲型H1N1流感暴露后预防是安全、有效的，耐受性良好，可预防甲型H1N1流感病毒感染，且与他克莫司水平无任何相互作用。奥司他韦对密切接触者的甲型H1N1流感暴露后预防有效。
