Govindasamy Chandramohan, Al-Numair Khalid S, Alsaif Mohammed A, Viswanathan Kodukkur Pugalendi
Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
J Asian Nat Prod Res. 2011 Aug;13(8):700-6. doi: 10.1080/10286020.2011.585157.
Casearia esculenta root (Roxb.) is widely used in traditional system of medicine to treat diabetes in India. An active compound, 3-hydroxymethyl xylitol (3-HMX), has been isolated, and its optimum dose has been determined in a short duration study and patented. In addition, the long-term effect of 3-HMX in type 2 diabetic rats on antihyperglycemic, antioxidants, antihyperlipidemic, and protein metabolism and kidney marker enzymes was investigated, and its effect was shown previously. In this study, we investigated the effect of 3-HMX on plasma and tissue glycoproteins in streptozotocin-diabetic rats. Animals were divided into five groups viz., control group, 3-HMX (40 mg/kg of body weight) treated group, diabetic group, diabetic+3-HMX (40 mg/kg of body weight), and diabetic+glibenclamide (600 μg/kg of body weight). 3-HMX was administered orally at a dose of 40 mg/kg of body weight for 45 days. The study shows significant increases in the level of sialic acid except kidney and elevated levels of hexose, hexosamine, and fucose in the liver and kidney of diabetic rats, and the treatment with 3-HMX and glibenclamide showed reversal of these parameters toward normalcy. Thus, the study indicates that 3-HMX possesses a significant beneficial effect on glycoprotein components.
印度传统医学广泛使用食用嘉赐树根（Roxb.）治疗糖尿病。一种活性化合物3-羟甲基木糖醇（3-HMX）已被分离出来，并且在一项短期研究中确定了其最佳剂量并已获得专利。此外，此前已研究了3-HMX对2型糖尿病大鼠的降血糖、抗氧化、降血脂、蛋白质代谢及肾脏标记酶的长期影响，且其效果已得到证实。在本研究中，我们研究了3-HMX对链脲佐菌素诱导的糖尿病大鼠血浆和组织糖蛋白的影响。动物被分为五组，即对照组、3-HMX（40毫克/千克体重）治疗组、糖尿病组、糖尿病+3-HMX（40毫克/千克体重）组和糖尿病+格列本脲（600微克/千克体重）组。以40毫克/千克体重的剂量口服给予3-HMX，持续45天。研究表明，糖尿病大鼠的肾脏除外，唾液酸水平显著升高，肝脏和肾脏中的己糖、己糖胺和岩藻糖水平升高，而3-HMX和格列本脲治疗使这些参数恢复正常。因此，该研究表明3-HMX对糖蛋白成分具有显著的有益作用。
