First Affiliated Hospital of Liaoning Medical University, Department of Orthopedics, and Liaoning Medical University, Department of Histology and Embryology, Jinzhou, PR China.
Med Hypotheses. 2011 Oct;77(4):589-90. doi: 10.1016/j.mehy.2011.06.037. Epub 2011 Jul 12.
Spinal cord repair is a challenging task that has puzzled clinical specialists and scientists for a long time. Zinc plays an important role in regulating the expression of brain-derived neurotrophic factor (BDNF) in nervous system, which can improve the pathological state of neurons and promote regeneration of injured neurons, reduce neuronal apoptosis. Our previous studies demonstrated that the serum zinc levels in SCI model group were significantly decreased and zinc concentrations in spinal cord were gradually increased in 24 h after SCI, which induces the up-regulation of zinc transporter 1 (ZnT-1). The mRNA levels of ZnT1 and BDNF were both increased after SCI, and there is a positive correlation between them. Excess zinc exposure has been proved to be a risk factor for neuron death in brain and spinal cord injuries, but supplement of the right amount of zinc may be useful in promoting the recovery of spinal cord function.
脊髓修复是一个具有挑战性的任务，长期以来一直困扰着临床专家和科学家。锌在调节神经系统中脑源性神经营养因子（BDNF）的表达方面发挥着重要作用，它可以改善神经元的病理状态，促进损伤神经元的再生，减少神经元凋亡。我们之前的研究表明，SCI 模型组的血清锌水平在 SCI 后 24 小时内显著降低，脊髓中的锌浓度逐渐升高，这会诱导锌转运蛋白 1（ZnT-1）的上调。SCI 后 ZnT1 和 BDNF 的 mRNA 水平均升高，且两者呈正相关。过量的锌暴露已被证明是脑和脊髓损伤中神经元死亡的一个危险因素，但是适量补充锌可能有助于促进脊髓功能的恢复。
