López Bernal A, Hansell D J, Khong T Y, Keeling J W, Turnbull A C
University of Oxford, Nuffield Department of Obstetrics and Gynaecology, U.K.
Early Hum Dev. 1990 Aug;23(2):93-9. doi: 10.1016/0378-3782(90)90132-3.
The production of leukotriene B4 (LTB4) by the human placenta in vitro was measured by radioimmunoassay. In early pregnancy (7-12 weeks gestation) LTB4 production rate (pmol/mg dry weight/2 h) was 3.7 (2.6-4.7) (median and range; n = 9) and at term it was 0.7 (0.4-2.3; n = 10) in placental tissue obtained at elective caesarean section, and 2.7 (1.3-3.6; n = 10) in samples following labour of spontaneous onset and vaginal delivery. In spontaneous preterm labour (26-36 weeks gestation) with normal placental histology LTB4 production was 0.7 (0.3-1.7; n = 14), but it was significantly higher in preterm placentas with inflammatory infiltration: 3.1 (0.8-4.8; n = 6). These data show that the production of LTB4 by human placenta is high in early pregnancy, but remains low during the third trimester, with a significant increase in spontaneous labour at term. LTB4 output is low in uncomplicated preterm labour but markedly increased in chorioamnionitis-associated preterm labour.
采用放射免疫分析法测定人胎盘体外白三烯B4（LTB4）的生成量。在妊娠早期（妊娠7 - 12周），择期剖宫产获取的胎盘组织中LTB4生成率（pmol/毫克干重/2小时）为3.7（2.6 - 4.7）（中位数及范围；n = 9），足月时为0.7（0.4 - 2.3；n = 10）；自然发动分娩并经阴道分娩的样本中LTB4生成率为2.7（1.3 - 3.6；n = 10）。在胎盘组织学正常的自然早产（妊娠26 - 36周）中，LTB4生成量为0.7（0.3 - 1.7；n = 14），但在有炎症浸润的早产胎盘中显著升高：3.1（0.8 - 4.8；n = 6）。这些数据表明，人胎盘LTB4生成量在妊娠早期较高，但在妊娠晚期保持较低水平，足月自然分娩时显著增加。单纯早产时LTB4产量较低，但绒毛膜羊膜炎相关早产时显著增加。
