López Bernal A, Hansell D J, Cañete Soler R, Keeling J W, Turnbull A C
John Radcliffe Hospital, Maternity Department, Headington, Oxford.
Br J Obstet Gynaecol. 1987 Dec;94(12):1156-8. doi: 10.1111/j.1471-0528.1987.tb02315.x.
The production of prostaglandin E (PGE) and leukotriene B4 (LTB4) by amnion was measured in vitro in 12 women delivered after spontaneous preterm labour and in 15 women delivered after spontaneous labour at term. The placenta and fetal membranes were examined histologically in all cases. PGE output (fmol/mg dry weight/2 h) in the amnions from uncomplicated preterm deliveries was low (median 486, range 232-3203, n = 7) compared with the values obtained after spontaneous labour at term (5529, 1722-14,226, n = 15). In amnions from preterm deliveries complicated by acute chorioamnionitis or round cell infiltration there was massive release of PGE (15,262, 10,905-27,640, n = 5) which was accompanied by an increase in LTB4 production. Inflammatory infiltration of the fetal membranes results in a huge increase in PG production which could cause preterm labour.
对12例自然早产分娩的女性和15例足月自然分娩的女性的羊膜进行体外前列腺素E（PGE）和白三烯B4（LTB4）生成量的测定。所有病例均对胎盘和胎膜进行了组织学检查。与足月自然分娩后获得的值（5529，1722 - 14226，n = 15）相比，单纯早产分娩的羊膜中PGE产量（fmol/毫克干重/2小时）较低（中位数486，范围232 - 3203，n = 7）。在并发急性绒毛膜羊膜炎或圆细胞浸润的早产分娩的羊膜中，PGE大量释放（15262，10905 - 27640，n = 5），同时LTB4生成增加。胎膜的炎性浸润导致PG生成大幅增加，这可能引发早产。
