螺旋千里光宁碱、乙酰化伪土木香内酯及其类似物：抗炎潜力的制备和评价。
Psilostachyin, acetylated pseudoguaianolides and their analogues: preparation and evaluation of their anti-inflammatory potential.
机构信息
Natural Product Microbes Division, Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, J&K, India.
出版信息
Bioorg Med Chem Lett. 2011 Aug 15;21(16):4847-51. doi: 10.1016/j.bmcl.2011.06.037. Epub 2011 Jun 22.
PMID:21752638
Abstract
Naturally occurring acetylated pseudoguaianolides and psilostachyin including their analogues were synthesized. The structure of semi-synthetic psilostachyin was also confirmed by X-ray crystallography. The anti-inflammatory potential of all the derivatives has been evaluated through in vitro expression of TNF-α, IL-1β and IL-6 in murine neutrophils.
摘要
天然存在的乙酰化伪土木香内酯和脒包括它们的类似物被合成。通过 X 射线晶体学也证实了半合成脒的结构。通过在小鼠嗜中性粒细胞中体外表达 TNF-α、IL-1β 和 IL-6 评估了所有衍生物的抗炎潜力。
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