Hypothesis testing: CTLA4 co-stimulatory pathways critical in the pathogenesis of human and mouse alopecia areata.
作者信息
Sundberg John P, McElwee Kevin J, Carroll Joseph M, King Lloyd E
出版信息
J Invest Dermatol. 2011 Nov;131(11):2323-4. doi: 10.1038/jid.2011.203. Epub 2011 Jul 14.
Abstract
摘要
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Hypothesis testing: CTLA4 co-stimulatory pathways critical in the pathogenesis of human and mouse alopecia areata.假设检验：CTLA4共刺激通路在人类和小鼠斑秃发病机制中起关键作用。
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本文引用的文献
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Genetic variants in CTLA4 are strongly associated with alopecia areata.细胞毒性T淋巴细胞相关抗原4（CTLA4）的基因变异与斑秃密切相关。
J Invest Dermatol. 2011 May;131(5):1169-72. doi: 10.1038/jid.2010.427. Epub 2011 Feb 24.
2
Anti-CTLA-4 antibody therapy: immune monitoring during clinical development of a novel immunotherapy.抗 CTLA-4 抗体治疗：新型免疫疗法临床开发期间的免疫监测。
Semin Oncol. 2010 Oct;37(5):473-84. doi: 10.1053/j.seminoncol.2010.09.001.
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Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.斑秃的全基因组关联研究提示固有免疫和适应性免疫均参与其中。
Nature. 2010 Jul 1;466(7302):113-7. doi: 10.1038/nature09114.
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Transcriptional profiling in alopecia areata defines immune and cell cycle control related genes within disease-specific signatures.斑秃中基因转录谱的研究定义了疾病特异性特征内与免疫和细胞周期控制相关的基因。
Genomics. 2010 Sep;96(3):146-53. doi: 10.1016/j.ygeno.2010.05.002. Epub 2010 May 28.
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Can animal models of disease reliably inform human studies?疾病的动物模型能可靠地为人类研究提供信息吗？
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The C3H/HeJ mouse and DEBR rat models for alopecia areata: review of preclinical drug screening approaches and results.斑秃的C3H/HeJ小鼠和DEBR大鼠模型：临床前药物筛选方法及结果综述
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