Hughes S, Smith M E
Department of Physiology, Medical School, University of Birmingham, U.K.
Neurosci Lett. 1990 Aug 14;116(1-2):29-33. doi: 10.1016/0304-3940(90)90381-i.
Autoradiography was used to investigate the presence of opioid receptors in soleus, extensor digitorum longus (EDL) and diaphragm muscles in two strains (C57BL/6J and C57BL/10) of mice which can inherit muscular dystrophy. Binding sites for two radiolabelled opioid ligands [125I]beta-endorphin and [3H]naloxone, were seen in a few muscle fibres in the normal mice. However, a significantly greater number of fibres exhibited the binding sites in the dystrophic individuals of both strains. The binding sites were not restricted to the endplate regions but were present over the entire surface in these fibres.
采用放射自显影术研究了两种可遗传性肌营养不良小鼠品系（C57BL/6J和C57BL/10）的比目鱼肌、趾长伸肌（EDL）和膈肌中阿片受体的存在情况。在正常小鼠的一些肌纤维中可见两种放射性标记阿片配体[125I]β-内啡肽和[3H]纳洛酮的结合位点。然而，在两个品系的营养不良个体中，有明显更多的纤维表现出结合位点。这些结合位点并不局限于终板区域，而是存在于这些纤维的整个表面。
