Evans A A, Smith M E
Department of Physiology, Medical School, University of Birmingham, Edgbaston, UK.
Peptides. 1996;17(4):629-34. doi: 10.1016/0196-9781(96)00068-x.
Autoradiography was used to demonstrate beta-endorphin and delta-opioid receptors in muscles of normal and obese-diabetic mice. The density of the receptors was significantly higher in the obese-diabetic mice. In both normal and diabetic mice, glycolytic and oxidative fibers exhibited the beta-endorphin receptors. However, a significantly greater density of beta-endorphin receptors was observed in the extensor digitorum longus muscles than in the soleus muscles in the diabetic mice. In normal muscles the beta-endorphin receptors were largely restricted to regions where endplates were present, but in the obese-diabetic mice they were densely distributed along the length of the muscle fibers.
利用放射自显影技术来显示正常小鼠和肥胖糖尿病小鼠肌肉中的β-内啡肽和δ阿片受体。肥胖糖尿病小鼠中受体的密度显著更高。在正常和糖尿病小鼠中，糖酵解纤维和氧化纤维均显示出β-内啡肽受体。然而，在糖尿病小鼠中，趾长伸肌中β-内啡肽受体的密度显著高于比目鱼肌。在正常肌肉中，β-内啡肽受体主要局限于终板所在区域，但在肥胖糖尿病小鼠中，它们沿肌纤维长度密集分布。
