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5''-(4-氯-亚苄基)-4'-(4-氯-苯基)-5-氟-1',1''-二甲基-吲哚啉-3-螺-2'-吡咯烷-3'-螺-3''-哌啶-2,4''-二酮

5''-(4-Chloro-benzyl-idene)-4'-(4-chloro-phen-yl)-5-fluoro-1',1''-dimethyl-indoline-3-spiro-2'-pyrrolidine-3'-spiro-3''-piperidine-2,4''-dione.

作者信息

Sundar J Kalyana, Bala B Devi, Natarajan S, Suresh J, Lakshman P L Nilantha

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 1;67(Pt 4):o801-2. doi: 10.1107/S1600536811007550. Epub 2011 Mar 5.

DOI:10.1107/S1600536811007550
PMID:21754090
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3099878/
Abstract

The piperidine ring of the title compound, C(30)H(26)Cl(2)FN(3)O(2), adopts a twisted chair conformation. The pyrrolidine ring has a twisted envelope structure with the N atom at the flap [displaced by 0.592 (3) Å]. The fluoro-oxindole, chloro-phenyl and chloro-benzyl-idene groups are planar with r.m.s. deviations of 0.0348, 0.0048 and 0.0048 Å, respectively. The structure is stabilized by inter-molecular N-H⋯O hydrogen bonds.

摘要

标题化合物C(30)H(26)Cl(2)FN(3)O(2)的哌啶环呈扭曲椅式构象。吡咯烷环具有扭曲信封式结构，N原子位于折边上[位移0.592 (3) Å]。氟代氧化吲哚、氯苯基和氯亚苄基基团均为平面结构，均方根偏差分别为0.0348、0.0048和0.0048 Å。该结构通过分子间N-H⋯O氢键得以稳定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2542/3099878/b3b5dbefa87b/e-67-0o801-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2542/3099878/1ed86c1bf972/e-67-0o801-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2542/3099878/b3b5dbefa87b/e-67-0o801-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2542/3099878/1ed86c1bf972/e-67-0o801-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2542/3099878/b3b5dbefa87b/e-67-0o801-fig2.jpg

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