Anagnostopoulos I, Hummel M, Kaudewitz P, Herbst H, Braun-Falco O, Stein H
Steglitz Medical Center, Free University of Berlin, Federal Republic of Germany.
Am J Pathol. 1990 Dec;137(6):1317-22.
To investigate the possibility that cutaneous T-cell lymphomas of large cell type may be associated with human T-cell leukemia/lymphoma virus type I infection in nonendemic regions, tissue samples from six cases of large cell cutaneous T-cell lymphoma and four cases of small cell cutaneous T-cell lymphoma were screened for the presence of integrated proviral human T-cell leukemia/lymphoma virus type I DNA. Combined use of Southern blot hybridization and enzymatic DNA amplification revealed human T-cell leukemia/lymphoma virus type I-specific sequences in all cases of large cell cutaneous T-cell lymphoma and in none of the cases of small cell cutaneous T-cell lymphoma. These results suggest that in nonendemic areas, a significant proportion of large cell cutaneous T-cell lymphoma cases are associated with human T-cell leukemia/lymphoma virus type I.
为了研究在非流行地区大细胞型皮肤T细胞淋巴瘤可能与I型人类T细胞白血病/淋巴瘤病毒感染相关的可能性，对6例大细胞皮肤T细胞淋巴瘤和4例小细胞皮肤T细胞淋巴瘤的组织样本进行筛查，以检测整合的前病毒I型人类T细胞白血病/淋巴瘤病毒DNA的存在。Southern印迹杂交和酶促DNA扩增联合使用显示，所有大细胞皮肤T细胞淋巴瘤病例中均存在I型人类T细胞白血病/淋巴瘤病毒特异性序列，而小细胞皮肤T细胞淋巴瘤病例中均未检测到。这些结果表明，在非流行地区，相当一部分大细胞皮肤T细胞淋巴瘤病例与I型人类T细胞白血病/淋巴瘤病毒有关。
