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Detection of HTLV-I proviral sequences in CD30-positive large cell cutaneous T-cell lymphomas.

作者信息

Anagnostopoulos I, Hummel M, Kaudewitz P, Herbst H, Braun-Falco O, Stein H

机构信息

Steglitz Medical Center, Free University of Berlin, Federal Republic of Germany.

出版信息

Am J Pathol. 1990 Dec;137(6):1317-22.

PMID:2175544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1877736/
Abstract

To investigate the possibility that cutaneous T-cell lymphomas of large cell type may be associated with human T-cell leukemia/lymphoma virus type I infection in nonendemic regions, tissue samples from six cases of large cell cutaneous T-cell lymphoma and four cases of small cell cutaneous T-cell lymphoma were screened for the presence of integrated proviral human T-cell leukemia/lymphoma virus type I DNA. Combined use of Southern blot hybridization and enzymatic DNA amplification revealed human T-cell leukemia/lymphoma virus type I-specific sequences in all cases of large cell cutaneous T-cell lymphoma and in none of the cases of small cell cutaneous T-cell lymphoma. These results suggest that in nonendemic areas, a significant proportion of large cell cutaneous T-cell lymphoma cases are associated with human T-cell leukemia/lymphoma virus type I.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f50/1877736/4f30fe0386e1/amjpathol00108-0048-a.jpg

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