Mehulić Muharem, Mehulić Ketij, Vuljanko Ivana Maloca, Kukulj Suzana, Grle Sanja Popović, Vukić Andrea Dugac, Barisić Blazenka, Plavec Davor
University of Zagreb, "Jordanovac" University Hospital for Lung Diseases, Zagreb, Croatia.
Coll Antropol. 2011 Jun;35(2):529-36.
Published data indicate that during the last decades there is a possible change in the pattern of sensitization to different aeroallergens in adult population with atopy. The aim of this investigation was based on the hypothesis that during last 15 years there has been a change in the structure of prevalence of sensitization to different aeroallergens in adult population of Zagreb and its surroundings with atopy. Medical records from outpatient allergy clinic were screened for the period 1991-2004. We included 794 patients during years 1991-1994, 814 patients during years 1995-1999, and 969 patients during years 2000-2004. Following data were analyzed: age, gender, education level, residence, referral diagnosis, dominant symptoms, results of skin-prick test (SPT), total and specific serum immunoglobulin E. As risk factors for allergic sensitization we determined the decade of birth (p < 0.0001), male gender (p < 0.008), level of education (p < 0.0001), and place of residence (p < 0.05). Proportion of sensitized individuals to pollen significantly increased from the period 1991-1994 towards 2000-2004 (p < 0.001 for the trend) with a significant increase in the proportion of sensitized individuals to weed pollen (p = 0.002 for the trend) while the proportion of sensitized to other two groups of pollen (grasses and trees) was not significantly different. A significant increase in the proportion of sensitized individuals was determined for sensitization to ragweed pollen (p = 0.004 for the trend), and to mugwort (p = 0.005 for the trend). Despite all its limitations primarily based on the selection bias the results of this study are conclusive about the significant change in the proportion of sensitization to different aeroallergens and different pollen groups and individual pollen species during the investigated 15-year time interval.
已发表的数据表明，在过去几十年中，特应性成年人群对不同气传变应原的致敏模式可能发生了变化。本研究的目的基于这样一个假设：在过去15年中，萨格勒布及其周边地区特应性成年人群对不同气传变应原的致敏流行结构发生了变化。对1991 - 2004年门诊过敏诊所的病历进行了筛查。我们纳入了1991 - 1994年的794例患者、1995 - 1999年的814例患者以及2000 - 2004年的969例患者。分析了以下数据：年龄、性别、教育水平、居住地址、转诊诊断、主要症状、皮肤点刺试验（SPT）结果、血清总免疫球蛋白E和特异性免疫球蛋白E。作为过敏性致敏的危险因素，我们确定了出生年代（p < 0.0001）、男性性别（p < 0.008）、教育水平（p < 0.0001）和居住地址（p < 0.05）。从1991 - 1994年到2000 - 2004年，对花粉致敏个体的比例显著增加（趋势p < 0.001），对杂草花粉致敏个体的比例显著增加（趋势p = 0.002），而对其他两组花粉（禾本科和树木）致敏的比例没有显著差异。对豚草花粉致敏个体的比例显著增加（趋势p = 0.004），对艾蒿致敏个体的比例也显著增加（趋势p = 0.005）。尽管本研究存在所有主要基于选择偏倚的局限性，但其结果对于在调查的15年时间间隔内对不同气传变应原、不同花粉组和单个花粉种类致敏比例的显著变化具有决定性意义。
