[支气管源性癌手术的时间线趋势]

[Timeline trends in surgery of bronchogenic carcinoma].

作者信息

Stolz A, Simonek J, Harustiak T, Schützner J, Pafko P, Lischke R

机构信息

III. chirurgická klinika 1. LF UK a FN Motol, Praha.

出版信息

Rozhl Chir. 2011 May;90(4):216-21.

PMID:21755902

Abstract

BACKGROUND

The aim of our study was to determine how patient preoperative status and outcomes of resection have changed over last 12 years.

MATERIAL AND METHODS

This retrospective study of prospective database included 1412 patients operated from January 1,1998 through December 31,2009. Patient characteristics and outcomes were compared for two time periods (1998-2003 and 2004-2009).

RESULTS

We performed 985 lobectomies with 30-days mortality 1.8% and 300 pneumonectomies with 30-days mortality 5.7%. Median of survival of all 1412 patients was 4.3 year and 5-year survival was 45%. The percentage of female patients, lobectomies and adenocarcinoma increased over time, as well as age of our patients. Outcome improved over time, with significant decrease in 30-days mortality after pneumonectomy (8.2% vs. 2.3%, p = 0.029). The overall 3-year survival improved in patients with III. stage (30 % vs. 40%, p = 0.012).

CONCLUSION

Our study identified time trends which are in-line with increased incidence of lung cancer among women and with improvement of preoperative evaluation, preoperative and postoperative care

摘要

背景

我们研究的目的是确定患者术前状态和切除结果在过去12年中是如何变化的。

材料与方法

这项对前瞻性数据库的回顾性研究纳入了1998年1月1日至2009年12月31日期间接受手术的1412例患者。对两个时间段（1998 - 2003年和2004 - 2009年）的患者特征和结果进行了比较。

结果

我们实施了985例肺叶切除术，30天死亡率为1.8%；300例全肺切除术，30天死亡率为5.7%。1412例患者的中位生存期为4.3年，5年生存率为45%。女性患者、肺叶切除术和腺癌的比例随时间增加，患者年龄也增加。随着时间推移，结果有所改善，全肺切除术后30天死亡率显著降低（8.2%对2.3%，p = 0.029）。Ⅲ期患者的总体3年生存率有所提高（30%对40%，p = 0.012）。