Hackett Eileen S, Gustafson Daniel L
Department of Clinical Sciences, Colorado State University, 300 West Drake Road, Fort Collins, CO 80523, USA.
Vet Clin North Am Small Anim Pract. 2011 Jul;41(4):805-15, vii. doi: 10.1016/j.cvsm.2011.03.019. Epub 2011 May 23.
Critically ill animals are by nature a diverse group with multiple presenting complaints and differing levels of organ function. Pharmacokinetics and pharmacodynamics of administered compounds are affected both by the disease processes and by the interventions of the treating veterinarian. Polypharmacy is not an exception but a rule within this caseload. Basic principles of pharmacology allow for safe and effective administration of pharmaceuticals, especially in the critically ill. Future research evaluating the pharmacokinetics and pharmacodynamics of drugs important in the management of critically ill animals is imperative, and will allow evidence-based dose modification.
危重病动物本质上是一个多样化的群体，有多种就诊主诉和不同程度的器官功能。所给药化合物的药代动力学和药效学既受疾病过程影响，也受治疗兽医的干预影响。联合用药在这类病例中并非例外，而是常态。药理学的基本原则有助于安全有效地用药，尤其是对危重病动物。评估对危重病动物治疗重要的药物的药代动力学和药效学的未来研究势在必行，这将有助于基于证据调整剂量。
