Dept of Clinical Pathology, Cleveland Clinic, Cleveland, OH 44195, USA.
Am J Clin Pathol. 2011 Aug;136(2):183-94. doi: 10.1309/AJCPV1I2QWKZKNJH.
B-cell lymphomas with plasmablastic features are a heterogeneous group of lymphomas. While they may share overlapping morphologic or immunophenotypic features, distinct clinicopathologic or molecular genetic features exist for some that have allowed their recognition as distinct entities. Session 2 of the 2009 Society for Hematopathology/European Association for Haematopathology Workshop dealt with the theme of plasmablastic lymphomas (PBLs) and related disorders. Topics included human herpesvirus 8-associated Castleman disease and PBLs, PBLs occurring in the setting of HIV infection, anaplastic large cell lymphoma kinase+ diffuse large B-cell lymphoma, and other lymphomas with plasmablastic or plasmacytic features. In this report, we review PBLs and related disorders in the context of submitted cases and illustrate key diagnostic points, highlight controversial areas, and provide recommendations on features that should be assessed and terminology that might be used when dealing with these lymphomas.
B 细胞淋巴瘤伴浆母细胞样特征是一组异质性的淋巴瘤。虽然它们可能具有重叠的形态学或免疫表型特征，但对于某些具有明确临床病理或分子遗传学特征的肿瘤，已经被认为是不同的实体。2009 年血液病理学协会/欧洲血液病理学协会研讨会的第 2 场涉及浆母细胞淋巴瘤（PBL）和相关疾病的主题。讨论的主题包括人类疱疹病毒 8 相关的卡斯特曼病和 PBL、HIV 感染背景下发生的 PBL、间变性大细胞淋巴瘤激酶阳性弥漫性大 B 细胞淋巴瘤以及具有浆母细胞样或浆细胞样特征的其他淋巴瘤。在本报告中，我们根据提交的病例回顾了 PBL 和相关疾病，并举例说明了关键的诊断要点，强调了有争议的领域，并就评估特征和使用术语提出了建议，这些内容在处理这些淋巴瘤时可能会用到。
