对氧磷酶2基因C311S多态性与波兰人群中大血管疾病性中风风险相关。
Paraoxonase 2 gene C311S polymorphism is associated with a risk of large vessel disease stroke in a Polish population.
作者信息
Slowik Agnieszka, Wloch Dorota, Szermer Pawel, Wolkow Pawel, Malecki Maciej, Pera Joanna, Turaj Wojciech, Dziedzic Tomasz, Klimkowicz-Mrowiec Aleksandra, Kopec Grzegorz, Figlewicz Denise A, Szczudlik Andrzej
机构信息
Department of Neurology, Jagiellonian University, Krakow, Poland.
出版信息
Cerebrovasc Dis. 2007;23(5-6):395-400. doi: 10.1159/000101462. Epub 2007 Apr 2.
BACKGROUND
Oxidative stress plays a role in atherosclerosis. Human paraoxonase (PON) gene products exhibit antioxidant properties. We studied the significance of the Q192R and M55L polymorphisms of the PON1 gene and the C311S polymorphism of the PON2 gene in different etiologies of ischemic stroke.
METHODS
One hundred and thirty-six patients with large vessel disease (LVD) stroke, 140 with small vessel disease stroke, 272 with cardioembolic stroke, and their age- and sex-matched controls were included. PON genotypes were evaluated by PCR-RFLP analyses.
RESULTS
The distribution of PON1 polymorphisms was similar in each stroke group and in the respective controls. Genotypes with the C allele of the PON2 gene C311S polymorphism were overrepresented in LVD stroke patients as compared with their controls, both in univariate and multivariate (dominant model: OR = 1.58, 95% CI: 1.006-2.48) analyses.
CONCLUSION
The genotype with the C allele of the PON2 gene is a risk factor for LVD stroke in a Polish population.
背景
氧化应激在动脉粥样硬化中起作用。人对氧磷酶（PON）基因产物具有抗氧化特性。我们研究了PON1基因的Q192R和M55L多态性以及PON2基因的C311S多态性在缺血性卒中不同病因中的意义。
方法
纳入136例大动脉疾病（LVD）性卒中患者、140例小血管疾病性卒中患者、272例心源性栓塞性卒中患者以及年龄和性别匹配的对照组。通过聚合酶链反应-限制性片段长度多态性分析评估PON基因型。
结果
在每个卒中组及其各自的对照组中，PON1多态性的分布相似。与对照组相比，PON2基因C311S多态性的C等位基因基因型在LVD卒中患者中占比过高，单因素和多因素（显性模型：OR = 1.58，95%CI：1.006 - 2.48）分析均如此。
结论
在波兰人群中，PON2基因的C等位基因基因型是LVD卒中的一个危险因素。
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