Goyal Nisha, Tiwari Ram Prakash, Shukla Geeta
Department of Microbiology, Panjab University, Chandigarh 160014, India.
Interdiscip Perspect Infect Dis. 2011;2011:795219. doi: 10.1155/2011/795219. Epub 2011 Jun 2.
The gut microflora is an important constituent in the intestinal mucosal barrier and has been introduced as the concept of probiotic therapy that beneficially affects the host by improving its intestinal microbial balance. Therefore, the main objective of the study was to explore the protective potential of various lactobacilli strains for murine giardiasis. By experimentation, it was found that the probiotic supplementation of either Lactobacillus casei, L. acidophilus, L. plantarum, or L. rhamnosus GG, 7 days prior to inoculation with G. lamblia trophozoites, reduced the rate of cyst excretion compared with Giardia-infected mice. Interestingly, L. GG was found to be the most effective probiotic in reducing the duration of giardia cycle and acts as an effective prophylactic probiotic for murine giardiasis but needs to be clinically correlated due to entirely different human microflora.
肠道微生物群是肠道黏膜屏障的重要组成部分，益生菌疗法的概念已被引入，即通过改善宿主肠道微生物平衡对宿主产生有益影响。因此，本研究的主要目的是探索各种乳酸杆菌菌株对小鼠贾第虫病的保护潜力。通过实验发现，在接种蓝氏贾第鞭毛虫滋养体前7天，补充干酪乳杆菌、嗜酸乳杆菌、植物乳杆菌或鼠李糖乳杆菌GG等益生菌，与感染贾第虫的小鼠相比，可降低包囊排泄率。有趣的是，发现鼠李糖乳杆菌GG是减少贾第虫周期持续时间最有效的益生菌，可作为小鼠贾第虫病的有效预防性益生菌，但由于人类微生物群完全不同，需要进行临床关联研究。
